p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis - Wikidata - awgldk - TriplyDB

p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

http://www.wikidata.org/entity/Q35419603

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Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition Stress kinases in the modulation of metabolism and energy balance Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly Xenobiotic perturbation of ER stress and the unfolded protein response Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus.The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes.BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K CDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP+-induced Parkinson's disease model Mechanisms of insulin resistance in obesity Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanism Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis.Suppression of XBP1S mediates high glucose-induced oxidative stress and extracellular matrix synthesis in renal mesangial cell and kidney of diabetic rats.Deficiency of the tumor promoter gene wip1 induces insulin resistance.p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients.Diet-induced unresolved ER stress hinders KRAS-driven lung tumorigenesis.Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells.MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response Parasite-induced ER stress response in hepatocytes facilitates Plasmodium liver stage infection.MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo.Way back for fructose and liver metabolism: bench side to molecular insights.Association between Serine/Threonine Kinase 39 Gene Polymorphism, Hypertension, and Other Cardiovascular Risk Factors in Koreans.XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells Potential for therapeutic manipulation of the UPR in disease.Effect of a p38 MAPK inhibitor on FFA-induced hepatic insulin resistance in vivo IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophy in vivo.Inflammation during obesity is not all bad: evidence from animal and human studies.The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells.Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice.Unfolded protein response signaling and metabolic diseases.Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity.IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance Targeting endoplasmic reticulum stress in metabolic disease.The role of the unfolded protein response in diabetes mellitus.XBP1s Is an Anti-lipogenic Protein.Proteostasis control by the unfolded protein response

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p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

http://www.wikidata.org/entity/Q35419603

description

2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

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p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

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type

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p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

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p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

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prefLabel

p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

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p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

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Nature Medicine

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p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

@en

P2093

Cheng Sun

http://www.w3.org/2001/XMLSchema#string

Deniz Gokalp

http://www.w3.org/2001/XMLSchema#string

Hilde Herrema

http://www.w3.org/2001/XMLSchema#string

Jaemin Lee

http://www.w3.org/2001/XMLSchema#string

Justin Lee

http://www.w3.org/2001/XMLSchema#string

Roger J Davis

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Sang Won Park

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Umut Ozcan

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Yingjiang Zhou

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

Inflammation and insulin resistance

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

Protective effect against Parkinson's disease-related insults through the activation of XBP1

The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

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1251-1260

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scholarly article

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10.1038/NM.2449

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P433

10

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17

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2011-09-04T00:00:00Z

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1016772084

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21892182

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4397266

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