Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. - Wikidata - awgldk - TriplyDB

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.

http://www.wikidata.org/entity/Q35471523

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Pancreatic cancer stem cell markers and exosomes - the incentive push Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives Biased and g protein-independent signaling of chemokine receptors Chemokines and chemokine receptors: update on utility and challenges for the clinician.Chemokine interaction with synergy-inducing molecules: fine tuning modulation of cell trafficking.Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine Secreted CXCL12 (SDF-1) forms dimers under physiological conditions.Microfluidic source-sink model reveals effects of biophysically distinct CXCL12 isoforms in breast cancer chemotaxis CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7.Inhibition of CXCL12/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma Chemokine receptor oligomerization and allostery.The role of chemoattractant receptors in shaping the tumor microenvironment.Chemokine cooperativity is caused by competitive glycosaminoglycan binding.Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction.Total body irradiation is permissive for mesenchymal stem cell-mediated new bone formation following local transplantation.Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: molecular modeling and experimental validation.Chemokine signaling in development and disease.Astrocytes directly influence tumor cell invasion and metastasis in vivo.CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis.Targeting chemokine receptor CXCR4 for treatment of HIV-1 infection, tumor progression, and metastasis.Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling Touch of chemokines.Preparation of unnatural N-to-N and C-to-C protein fusions Chemokines in colitis: microRNA control.Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation.Protein expression changes during human triple negative breast cancer cell line progression to lymph node metastasis in a xenografted model in nude mice A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability NMR in the Analysis of Functional Chemokine Interactions and Drug Discovery Inverse expression of somatostatin and CXCR4 chemokine receptors in gastroenteropancreatic neuroendocrine neoplasms of different malignancy Mesenchymal stem cell expression of stromal cell-derived factor-1β augments bone formation in a model of local regenerative therapy.Caloric restriction and the adipokine leptin alter the SDF-1 signaling axis in bone marrow and in bone marrow derived mesenchymal stem cells.Structural perspectives on antimicrobial chemokines.The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization Preparation and Analysis of N-Terminal Chemokine Receptor Sulfopeptides Using Tyrosylprotein Sulfotransferase Enzymes.Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor.CXCL12 induces hepatic stellate cell contraction through a calcium-independent pathway.Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery.The role of tyrosine sulfation in the dimerization of the CXCR4:SDF-1 complex.

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Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.

http://www.wikidata.org/entity/Q35471523

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2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Monomeric and dimeric CXCL12 i ...... ctions and signaling pathways.

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Monomeric and dimeric CXCL12 i ...... ctions and signaling pathways.

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Monomeric and dimeric CXCL12 i ...... ctions and signaling pathways.

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Monomeric and dimeric CXCL12 i ...... ctions and signaling pathways.

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Monomeric and dimeric CXCL12 i ...... ctions and signaling pathways.

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Monomeric and dimeric CXCL12 i ...... ctions and signaling pathways.

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Proceedings of the National Academy of Sciences of the United States of America

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Monomeric and dimeric CXCL12 i ...... ctions and signaling pathways.

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Brian F Volkman

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Christopher T Veldkamp

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Luke J Drury

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Michael B Dwinell

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Nikolaus Heveker

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Samuel T Hwang

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Stéphanie Gravel

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Tomonori Takekoshi

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P2860

Involvement of chemokine receptors in breast cancer metastasis

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity

On-column refolding of recombinant chemokines for NMR studies and biological assays.

CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis.

Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer

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10.1073/PNAS.1101133108

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43

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108

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Joshua J Ziarek

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51709915

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