Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.
about
SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysMn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathwaysMnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene.Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer.FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target.Anticancer therapeutic potential of Mn porphyrin/ascorbate systemX-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity.Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.MnTnBuOE-2-PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio/chemotherapeutic killing of colorectal cancer cellsSuperoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum.Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).Simple biological systems for assessing the activity of superoxide dismutase mimics.The unpaved journey of vitamin C in cancer treatment.Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.Differential effects of superoxide dismutase and superoxide dismutase/catalase mimetics on human breast cancer cells.A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications.Pharmacological doses of daily ascorbate protect tumors from radiation damage after a single dose of radiation in an intracranial mouse glioma model.Catalytic Radical Reduction in Aqueous Solution by a Ruthenium Hydride Intermediate.The SOD Mimic, MnTE-2-PyP, Protects from Chronic Fibrosis and Inflammation in Irradiated Normal Pelvic Tissues.IMMUNEPOTENT CRP induces cell cycle arrest and caspase-independent regulated cell death in HeLa cells through reactive oxygen species production.Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.Dehydroascorbic Acid Promotes Cell Death in Neurons Under Oxidative Stress: a Protective Role for Astrocytes.The Addition of Manganese Porphyrins during Radiation Inhibits Prostate Cancer Growth and Simultaneously Protects Normal Prostate Tissue from Radiation Damage.Radiation-mediated tumor growth inhibition is significantly enhanced with redox-active compounds that cycle with ascorbate.Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}(6) complex.
P2860
Q28385000-91E5FB6A-C650-445F-B934-4542A281EB8AQ28389277-2F47D390-8AEC-4B22-BDC7-DF4A740738A5Q33841634-5F045F98-7A7C-4249-8186-CCE848A50C1DQ34455737-405BB2A0-34CF-43CD-AE4D-01417590925DQ35349280-1F317C6D-D130-4FD5-A1F9-F28C0EAEE98BQ35825566-1A72CD38-23A7-4652-B953-A51CE3768794Q36352352-E1AA58CD-F2F2-453B-AAAC-DF9186EBD29EQ36386390-2C09129F-F60C-45CE-8B3B-07975F5B04CEQ36751784-E15B11B5-3D8C-4B6F-ABDE-38AB01452AD2Q37049935-CF5DCF2C-A269-40C0-AAC1-81D6BFEFA8EFQ37376329-B8F73707-4F76-43AC-8813-EFF2EECDA53BQ37393754-BC8D235B-3B9A-47AB-AE7F-FA624D2188CAQ37629336-34240E01-2BA6-4D77-B7B9-E65103A82CE3Q37734019-DE139CC1-EB12-4830-A7C1-8FA383B37CFDQ38561256-46BD817B-7787-4F2D-B236-6EFAD34B197DQ38768495-558A94E2-F9DA-4805-B4D4-C9665715EFDAQ38897004-C087FAA6-EA77-47CC-AA26-F8E6F9416F30Q41812704-04B40E31-AAAD-48C3-9F71-51F47DD615ECQ41876611-8232915A-7630-4059-A161-E8C7DC87FE76Q42625912-5A8BCEDF-0540-4A65-B115-9E7E728EAB3DQ46538652-D200A334-0229-47C9-AAF0-7CF84DD063B9Q47112999-A7CA3376-E839-4F44-8DFD-7A470D947998Q47213314-CAC14E0A-2F02-4BF0-9936-5260336ACCB4Q48207665-48AC15D3-E87D-41E4-89AE-6B53A0FC7210Q48451491-99D9E292-F493-444E-BA23-730346B68170Q49184042-E3A89841-3FFA-4BBE-8D3F-EAF8DB13B53AQ49484285-1C568A97-DDDF-4C39-B2B5-1FF90B8FC256Q53009873-9768ADFC-AE03-48ED-8E1D-52D89206BA23
P2860
Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.
description
2013 nî lūn-bûn
@nan
2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Mn porphyrin in combination wi ...... independent cancer cell death.
@ast
Mn porphyrin in combination wi ...... independent cancer cell death.
@en
type
label
Mn porphyrin in combination wi ...... independent cancer cell death.
@ast
Mn porphyrin in combination wi ...... independent cancer cell death.
@en
prefLabel
Mn porphyrin in combination wi ...... independent cancer cell death.
@ast
Mn porphyrin in combination wi ...... independent cancer cell death.
@en
P2860
P1476
Mn porphyrin in combination wi ...... independent cancer cell death.
@en
P2093
Gayathri R Devi
Ines Batinic-Haberle
P2860
P304
P356
10.1016/J.FREERADBIOMED.2013.11.031
P577
2013-12-12T00:00:00Z