Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC
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Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and miceBorrelia burgdorferi changes its surface antigenic expression in response to host immune responsesPersistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infectionCrystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi.The TamB ortholog of Borrelia burgdorferi interacts with the β-barrel assembly machine (BAM) complex protein BamAThe Borrelia burgdorferi 37-kilodalton immunoblot band (P37) used in serodiagnosis of early lyme disease is the flaA gene product.A monoclonal antibody generated by antigen inoculation via tick bite is reactive to the Borrelia burgdorferi Rev protein, a member of the 2.9 gene family locusComparison of protection in rabbits against host-adapted and cultivated Borrelia burgdorferi following infection-derived immunity or immunization with outer membrane vesicles or outer surface protein A.Inhibition of the production of anti-OspA borreliacidal antibody with T cells from hamsters vaccinated against Borrelia burgdorferiActive and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection.The dominant epitope of Borrelia garinii outer surface protein C recognized by sera from patients with neuroborreliosis has a surface-exposed conserved structural motifMolecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of Borrelia burgdorferi sensu lato.One-year duration of immunity induced by vaccination with a canine Lyme disease bacterin.Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans.Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway.Genetic diversity of the outer surface protein C gene of southern Borrelia isolates and its possible epidemiological, clinical, and pathogenetic implications.Specificity of infection-induced immunity among Borrelia burgdorferi sensu lato speciesConformational nature of the Borrelia burgdorferi B31 outer surface protein C protective epitope.An OspC-specific monoclonal antibody passively protects mice from tick-transmitted infection by Borrelia burgdorferi B31.Population dynamics of a naturally occurring heterogeneous mixture of Borrelia burgdorferi clones.Inhibition of Borrelia burgdorferi migration from the midgut to the salivary glands following feeding by ticks on OspC-immunized mice.Protection elicited by native outer membrane protein Oms66 (p66) against host-adapted Borrelia burgdorferi: conformational nature of bactericidal epitopes.C-terminal invariable domain of VlsE may not serve as target for protective immune response against Borrelia burgdorferi.VraA (BBI16) protein of Borrelia burgdorferi is a surface-exposed antigen with a repetitive motif that confers partial protection against experimental Lyme borreliosis.DNA vaccines expressing a fusion product of outer surface proteins A and C from Borrelia burgdorferi induce protective antibodies suitable for prophylaxis but Not for resolution of Lyme diseaseMajor histocompatibility complex class II-independent generation of neutralizing antibodies against T-cell-dependent Borrelia burgdorferi antigens presented by dendritic cells: regulation by NK and gammadelta T cells.Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis alters murine immune responses, pathogen burden, and severity of Lyme arthritis.Interleukin-6 enhances production of anti-OspC immunoglobulin G2b borreliacidal antibody.Conformational nature of the Borrelia burgdorferi decorin binding protein A epitopes that elicit protective antibodiesVariable tick protein in two genomic groups of the relapsing fever spirochete Borrelia hermsii in western North AmericaEvolution and distribution of the ospC Gene, a transferable serotype determinant of Borrelia burgdorferiGenetics of Borrelia burgdorferiVaccination against Lyme disease: past, present, and futureospC diversity in Borrelia burgdorferi: different hosts are different niches.Genetic diversity of ospC in a local population of Borrelia burgdorferi sensu stricto.Inferring epitopes of a polymorphic antigen amidst broadly cross-reactive antibodies using protein microarrays: a study of OspC proteins of Borrelia burgdorferiProtective niche for Borrelia burgdorferi to evade humoral immunityA host-restricted viral vector for antigen-specific immunization against Lyme disease pathogen.Resistance to tick-borne spirochete challenge induced by Borrelia burgdorferi strains that differ in expression of outer surface proteins.Borrelia burgdorferi-pulsed dendritic cells induce a protective immune response against tick-transmitted spirochetes.
P2860
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P2860
Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Outer surface protein C (OspC) ...... nal protective epitope in OspC
@ast
Outer surface protein C (OspC) ...... nal protective epitope in OspC
@en
type
label
Outer surface protein C (OspC) ...... nal protective epitope in OspC
@ast
Outer surface protein C (OspC) ...... nal protective epitope in OspC
@en
prefLabel
Outer surface protein C (OspC) ...... nal protective epitope in OspC
@ast
Outer surface protein C (OspC) ...... nal protective epitope in OspC
@en
P2093
P2860
P1476
Outer surface protein C (OspC) ...... nal protective epitope in OspC
@en
P2093
Gilmore RD Jr
Johnson BJ
P2860
P304
P407
P577
1996-06-01T00:00:00Z