Shiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2
about
Do the A subunits contribute to the differences in the toxicity of Shiga toxin 1 and Shiga toxin 2?Solution structure of human P1*P2 heterodimer provides insights into the role of eukaryotic stalk in recruiting the ribosome-inactivating protein trichosanthin to the ribosomePhosphorylation of initiation factor eIF2 in response to stress conditions is mediated by acidic ribosomal P1/P2 proteins in Saccharomyces cerevisiae.The A1 Subunit of Shiga Toxin 2 Has Higher Affinity for Ribosomes and Higher Catalytic Activity than the A1 Subunit of Shiga Toxin 1.Differences in Ribosome Binding and Sarcin/Ricin Loop Depurination by Shiga and Ricin HolotoxinsHuman ribosomal P1-P2 heterodimer represents an optimal docking site for ricin A chain with a prominent role for P1 C-terminus.Interaction of ricin and Shiga toxins with ribosomesMaize ribosome-inactivating protein uses Lys158-lys161 to interact with ribosomal protein P2 and the strength of interaction is correlated to the biological activities.Wild type RTA and less toxic variants have distinct requirements for Png1 for their depurination activity and toxicity in Saccharomyces cerevisiaeN-glycosylation does not affect the catalytic activity of ricin a chain but stimulates cytotoxicity by promoting its transport out of the endoplasmic reticulum.Targeting ricin to the ribosome.Conserved Arginines at the P-Protein Stalk Binding Site and the Active Site Are Critical for Ribosome Interactions of Shiga Toxins but Do Not Contribute to Differences in the Affinity of the A1 Subunits for the Ribosome.Structures of eukaryotic ribosomal stalk proteins and its complex with trichosanthin, and their implications in recruiting ribosome-inactivating proteins to the ribosomes.Shiga toxins: from structure and mechanism to applications.Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome.Different roles of the C-terminal end of Stx1A and Stx2A for AB5 complex integrity and retrograde transport of Stx in HeLa cells.Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins.Peptide Mimics of the Ribosomal P Stalk Inhibit the Activity of Ricin A Chain by Preventing Ribosome Binding
P2860
Q26858938-735F583E-673A-4601-BA12-29A32E2D30F8Q27679227-6544568C-4A7A-4B70-95AD-2972B6AF55F8Q27937914-7D342D03-446E-47D7-9194-B035DE4AF568Q33426867-3350E4BA-A657-49F2-ABDD-74F643D2D73AQ33612042-BE38BD88-B104-4FC0-9826-706A9D59DEB8Q33911820-42BA76FA-4305-45AE-BD0E-B0B257F43571Q33921062-7588DD4D-1936-4C4B-BC7F-1ED41DE9FE32Q34515656-D7259726-134B-45DD-A136-09872A606C1FQ35462730-ED3629CB-B89C-4853-BD3B-E87A10343CFEQ36301063-7883AD16-2661-4D30-811D-29DFC77A1813Q36901746-410D571B-88A4-41DC-9EDD-B24CD762883EQ37424949-1D8E7FCA-D1D9-4D8A-9E73-106C14EA88B0Q38365820-FA31A040-48A2-4935-93B3-F4B69DCE2C14Q38674171-F988D577-6699-48E0-A82C-9A1E1ED22296Q38745809-45B0E1A4-3716-4625-AD49-5ABB309D0B4BQ43196106-74A67D31-1E52-4FC4-85F8-2A95CAAF7E04Q55515121-ABCC04E5-21C7-467E-9605-D0E2054A26E8Q58742640-B3DCDAD5-4538-4CCE-8E7B-0F0BEE0B6A0F
P2860
Shiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Shiga toxin 1 is more dependen ...... on activity than Shiga toxin 2
@ast
Shiga toxin 1 is more dependen ...... on activity than Shiga toxin 2
@en
type
label
Shiga toxin 1 is more dependen ...... on activity than Shiga toxin 2
@ast
Shiga toxin 1 is more dependen ...... on activity than Shiga toxin 2
@en
prefLabel
Shiga toxin 1 is more dependen ...... on activity than Shiga toxin 2
@ast
Shiga toxin 1 is more dependen ...... on activity than Shiga toxin 2
@en
P2093
P2860
P1476
Shiga toxin 1 is more dependen ...... on activity than Shiga toxin 2
@en
P2093
Jia-Chi Chiou
Juan P G Ballesta
Miguel Remacha
Nilgun E Tumer
Xiao-Ping Li
P2860
P304
P356
10.1016/J.BIOCEL.2011.08.018
P577
2011-09-03T00:00:00Z