Specific sites within the ligand-binding domain and ion channel linkers modulate NMDA receptor gating
about
Structure, Dynamics, and Allosteric Potential of Ionotropic Glutamate Receptor N-Terminal DomainsNovel NMDA receptor modulators: an updateFunctional insights from glutamate receptor ion channel structuresNMDA receptor modulators: an updated patent review (2013-2014)GluN1-specific redox effects on the kinetic mechanism of NMDA receptor activationGenetically encoding a light switch in an ionotropic glutamate receptor reveals subunit-specific interfaces.GRIN2A mutation and early-onset epileptic encephalopathy: personalized therapy with memantine.Mechanical coupling maintains the fidelity of NMDA receptor-mediated currentsCysteine substitution of transmembrane domain amino acids alters the ethanol inhibition of GluN1/GluN2A N-methyl-D-aspartate receptors.Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulatorsArrangement of subunits in functional NMDA receptors.Interaction of the M4 segment with other transmembrane segments is required for surface expression of mammalian α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.New advances in NMDA receptor pharmacology.Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.Contribution of the M1 transmembrane helix and pre-M1 region to positive allosteric modulation and gating of N-methyl-D-aspartate receptorsAn NMDA receptor gating mechanism developed from MD simulations reveals molecular details underlying subunit-specific contributions.Disruption of S2-M4 linker coupling reveals novel subunit-specific contributions to N-methyl-d-aspartate receptor function and ethanol sensitivity.GRIN2A mutations cause epilepsy-aphasia spectrum disorders.Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy.Molecular basis of NMDA receptor functional diversity.Induction of cross-linking and silencing of Sp1 by transglutaminase during liver injury in ASH and NASH via different ER stress pathways.Synaptic neurotransmitter-gated receptorsStructural mechanisms of activation and desensitization in neurotransmitter-gated ion channels.Gating Motions and Stationary Gating Properties of Ionotropic Glutamate Receptors: Computation Meets Electrophysiology.Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.Control of AMPA receptor activity by the extracellular loops of auxiliary proteins.Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors.Mechanism-Based Mathematical Model for Gating of Ionotropic Glutamate Receptors.Asynchronous movements prior to pore opening in NMDA receptors.Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors.NMDA Receptors in the Central Nervous System.Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy.Structural modeling for the open state of an NMDA receptor.A conserved glycine harboring disease-associated mutations permits NMDA receptor slow deactivation and high Ca permeabilityA structurally derived model of subunit-dependent NMDA receptor function
P2860
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P2860
Specific sites within the ligand-binding domain and ion channel linkers modulate NMDA receptor gating
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Specific sites within the liga ...... modulate NMDA receptor gating
@ast
Specific sites within the liga ...... modulate NMDA receptor gating
@en
type
label
Specific sites within the liga ...... modulate NMDA receptor gating
@ast
Specific sites within the liga ...... modulate NMDA receptor gating
@en
prefLabel
Specific sites within the liga ...... modulate NMDA receptor gating
@ast
Specific sites within the liga ...... modulate NMDA receptor gating
@en
P2093
P2860
P1476
Specific sites within the liga ...... modulate NMDA receptor gating
@en
P2093
Iehab Talukder
Lonnie P Wollmuth
Priya Borker
P2860
P304
11792-11804
P356
10.1523/JNEUROSCI.5382-09.2010
P407
P577
2010-09-01T00:00:00Z