Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells - Wikidata - awgldk - TriplyDB

Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells

Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells

http://www.wikidata.org/entity/Q35539335

about

Molecular targeted approaches to cancer therapy and prevention using chalcones Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway Complete assignments of 1H and 13C NMR data for 21 naphthalenyl-phenyl-pyrazoline derivatives.A synthetic chalcone as a potent inducer of glutathione biosynthesis Synthetic chalcones with potent antioxidant ability on H₂O₂-induced apoptosis in PC12 cells.Screening of natural compounds as activators of the keap1-nrf2 pathway.Imine resveratrol analogues: molecular design, Nrf2 activation and SAR analysis Gene-expression analysis of early- and late-maturation-stage rat enamel organ.Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease.Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity.NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.Pharmacological antioxidant strategies as therapeutic interventions for COPD.Antioxidant pharmacological therapies for COPD.Epigenetic mechanisms in COPD: implications for pathogenesis and drug discovery.Chalcone-based carbamates for Alzheimer's disease treatment.The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases.Synthesis and cytotoxic evaluation of alkoxylated chalcones.Discovery of 2'-hydroxychalcones as autophagy inducer in A549 lung cancer cells.Chalcone: A Privileged Structure in Medicinal Chemistry.Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption.(E)-3-(3,4-Di-fluoro-phen-yl)-1-(3,4-di-meth-oxy-phen-yl)prop-2-en-1-one.The Role of Nrf2 in Cardiovascular Function and Disease.Facile synthesis of some pyrazoline-based compounds with promising anti-inflammatory activity.Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells.

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Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells

http://www.wikidata.org/entity/Q35539335

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Novel chalcone derivatives as ...... nd human lung epithelial cells

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Novel chalcone derivatives as ...... nd human lung epithelial cells

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Journal of Medicinal Chemistry

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Novel chalcone derivatives as ...... nd human lung epithelial cells

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P2093

Amit Kumar

http://www.w3.org/2001/XMLSchema#string

Hailong Wu

http://www.w3.org/2001/XMLSchema#string

Mohammad Hassan

http://www.w3.org/2001/XMLSchema#string

Rajesh K Thimmulappa

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Sanjay V Malhotra

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Sarvesh Kumar

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Shyam Biswal

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Sunil K Sharma

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Vineet Kumar

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Virinder S Parmar

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P2860

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

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4147-4159

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10.1021/JM2002348

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12

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54

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3212436

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