Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production. - Wikidata - awgldk - TriplyDB

Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production.

Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production.

http://www.wikidata.org/entity/Q35540125

about

The pre-B cell receptor; selecting for or against autoreactivity Primary immunoglobulin repertoire development: time and space matter Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic.Exposure to the Epstein-Barr Viral Antigen Latent Membrane Protein 1 Induces Myelin-Reactive Antibodies In Vivo The promise and challenge of high-throughput sequencing of the antibody repertoire.Clonal Progression during the T Cell-Dependent B Cell Antibody Response Depends on the Immunoglobulin DH Gene Segment Repertoire.The Antibody Germline/Maturation Hypothesis, Elicitation of Broadly Neutralizing Antibodies Against HIV-1 and Cord Blood IgM Repertoires The pre-B cell receptor checkpoint.Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes.Receptor editing in lymphocyte development and central tolerance.Violation of an evolutionarily conserved immunoglobulin diversity gene sequence preference promotes production of dsDNA-specific IgG antibodies.Absence of N addition facilitates B cell development, but impairs immune responses.Limiting CDR-H3 diversity abrogates the antibody response to the bacterial polysaccharide α 1→3 dextran.Partial versus productive immunoglobulin heavy locus rearrangements in chronic lymphocytic leukemia: implications for B-cell receptor stereotypy Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoire Generation and analyses of human synthetic antibody libraries and their application for protein microarrays.The role of evolutionarily conserved germ-line DH sequence in B-1 cell development and natural antibody production.Molecular characterization of the early B cell response to pulmonary Cryptococcus neoformans infection.HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence.Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation.Recirculating bone marrow B cells in C57BL/6 mice are more tolerant of highly hydrophobic and highly charged CDR-H3s than those in BALB/c mice.Immunoglobulin class switching appears to be regulated by B-cell antigen receptor-specific T-cell action.Immunogenetic characteristics of immunoglobulin E in allergic disease.The Global Self-Reactivity Profile of the Natural Antibody Repertoire Is Largely Independent of Germline DH Sequence.Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production Regulation of repertoire development through genetic control of DH reading frame preference A hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR.Differences in the composition of the human antibody repertoire by B cell subsets in the blood.VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites.Genetic control of DH reading frame and its effect on B-cell development and antigen-specifc antibody production.The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire.Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire.Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions.The peritoneal cavity B-2 antibody repertoire appears to reflect many of the same selective pressures that shape the B-1a and B-1b repertoires.The CDR-H3 repertoire from TdT-deficient adult bone marrow is a close, but not exact, homologue of the CDR-H3 repertoire from perinatal liver.Immunoglobulin analysis tool: a novel tool for the analysis of human and mouse heavy and light chain transcripts.DH and JH usage in murine fetal liver mirrors that of human fetal liver

P2860

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P2860

Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production.

http://www.wikidata.org/entity/Q35540125

description

2006 nî lūn-bûn

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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հունիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Forced usage of positively cha ...... pment and antibody production.

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Forced usage of positively cha ...... pment and antibody production.

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type

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Forced usage of positively cha ...... pment and antibody production.

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Forced usage of positively cha ...... pment and antibody production.

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P1433

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P2860

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P1433

Journal of Experimental Medicine

P1476

Forced usage of positively cha ...... pment and antibody production.

@en

P2093

Cosima Zemlin

http://www.w3.org/2001/XMLSchema#string

G Larry Gartland

http://www.w3.org/2001/XMLSchema#string

Harry W Schroeder

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Ivaylo I Ivanov

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Jukka Pelkonen

http://www.w3.org/2001/XMLSchema#string

Kohtaro Fujihashi

http://www.w3.org/2001/XMLSchema#string

Lars Nitschke

http://www.w3.org/2001/XMLSchema#string

Robert L Schelonka

http://www.w3.org/2001/XMLSchema#string

Ryoki Kobayashi

http://www.w3.org/2001/XMLSchema#string

P2860

Direct in vivo VH to JH rearrangement violating the 12/23 rule.

Somatic generation of antibody diversity

Predominant autoantibody production by early human B cell precursors

Neutralization of tetanus toxin by distinct monoclonal antibodies binding to multiple epitopes on the toxin molecule.

Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures.

Most peripheral B cells in mice are ligand selected.

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation

B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

Revising B cell receptors

Anatomy of the antibody molecule.

P304

1567-1578

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scholarly article

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10.1084/JEM.20052217

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P433

6

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203

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P50

Gregory C Ippolito

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2006-06-05T00:00:00Z

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7027751

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16754718

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3212734

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