Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model - Wikidata - awgldk - TriplyDB

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

http://www.wikidata.org/entity/Q35546692

about

Structural insights for activation of retinal guanylate cyclase by GCAP1 Production of cloned pigs with targeted attenuation of gene expression.Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones.Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies RNAi-mediated gene suppression in a GCAP1(L151F) cone-rod dystrophy mouse model Evaluating the role of retinal membrane guanylyl cyclase 1 (RetGC1) domains in binding guanylyl cyclase-activating proteins (GCAPs)Heterotrimeric kinesin-2 (KIF3) mediates transition zone and axoneme formation of mouse photoreceptors Calcium-myristoyl Tug is a new mechanism for intramolecular tuning of calcium sensitivity and target enzyme interaction for guanylyl cyclase-activating protein 1: dynamic connection between N-fatty acyl group and EF-hand controls calcium sensitivity Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function.cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function.Identification of target binding site in photoreceptor guanylyl cyclase-activating protein 1 (GCAP1).Centrin 2 is required for mouse olfactory ciliary trafficking and development of ependymal cilia planar polarity.Progress in gene therapy for neurological disorders.Epigenetics and ocular diseases: from basic biology to clinical study.RNA interference gene therapy in dominant retinitis pigmentosa and cone-rod dystrophy mouse models caused by GCAP1 mutations.Retinal prosthetics, optogenetics, and chemical photoswitches Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein.Dysfunction of outer segment guanylate cyclase caused by retinal disease related mutations.RNAi-mediated knockdown of IKK1 in transgenic mice using a transgenic construct containing the human H1 promoter.

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P2860

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

http://www.wikidata.org/entity/Q35546692

description

2011 nî lūn-bûn

@nan

2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

@ast

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

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type

label

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

@ast

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

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prefLabel

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

@ast

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

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PNAS.1112758108

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

@en

P2093

Alexander M Dizhoor

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Houbin Zhang

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Jeanne M Frederick

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Li Jiang

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Shannon E Boye

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Wolfgang Baehr

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P2860

Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily

Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy.

A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD)

Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice

A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1

Autosomal dominant cone and cone-rod dystrophy with mutations in the guanylate cyclase activator 1A gene-encoding guanylate cyclase activating protein-1

Current prospects for RNA interference-based therapies

Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy

Constitutive activation of photoreceptor guanylate cyclase by Y99C mutant of GCAP-1. Possible role in causing human autosomal dominant cone degeneration

GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy

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18476-18481

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scholarly article

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10.1073/PNAS.1112758108

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45

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108

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William W Hauswirth

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2011-10-31T00:00:00Z

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51760180

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3215008

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