Chemogenomic profiling: identifying the functional interactions of small molecules in yeast - Wikidata - awgldk - TriplyDB

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

http://www.wikidata.org/entity/Q35554300

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Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations Diazaborine treatment of yeast cells inhibits maturation of the 60S ribosomal subunit Noise minimization in eukaryotic gene expression Chemical genomics in yeast The uses of genome-wide yeast mutant collections Cytological profiling: providing more haystacks for chemists' needles.Genome-wide requirements for resistance to functionally distinct DNA-damaging agents.Improved microarray methods for profiling the Yeast Knockout strain collection.Detection of compound mode of action by computational integration of whole-genome measurements and genetic perturbations.A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis The Mcm2-7 replicative helicase: a promising chemotherapeutic target Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.Interaction of the deubiquitinating enzyme Ubp2 and the e3 ligase Rsp5 is required for transporter/receptor sorting in the multivesicular body pathway.5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs.Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection.Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks Chemogenomics: an emerging strategy for rapid target and drug discovery Yeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnology Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection Mitochondrial electron transport is the cellular target of the oncology drug elesclomol Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity A Ham1p-dependent mechanism and modulation of the pyrimidine biosynthetic pathway can both confer resistance to 5-fluorouracil in yeast Inducible knockdown of Plasmodium gene expression using the glmS ribozyme Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines Death by a thousand cuts: the challenges and diverse landscape of lignocellulosic hydrolysate inhibitors An interactive visualization tool to explore the biophysical properties of amino acids and their contribution to substitution matrices The chemical genomic portrait of yeast: uncovering a phenotype for all genes Large-scale reverse docking profiles and their applications.Quantitative phenotyping via deep barcode sequencing.Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method.TagSmart: analysis and visualization for yeast mutant fitness data measured by tag microarrays.

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P2860

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

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Angela M Chu

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Corey Nislow

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Daniel F Jaramillo

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Guri Giaever

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Jochen Kumm

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Michael Proctor

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Ronald W Davis

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P2860

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

Functional profiling of the Saccharomyces cerevisiae genome

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin

Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase

The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway.

Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane

A gene expression database for the molecular pharmacology of cancer

Lovastatin and simvastatin--inhibitors of HMG CoA reductase and cholesterol biosynthesis.

Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain.

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793-798

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Michael I. Jordan

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8922121

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