The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
about
The current state of eukaryotic DNA base damage and repairDestabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylaseNo cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient miceHuman Telomere G-Quadruplexes with Five Repeats Accommodate 8-Oxo-7,8-dihydroguanine by Looping out the DNA Damage.A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These "Spare Tires" Have an Evolved Function?Xanthine and 8-oxoguanine in G-quadruplexes: formation of a G·G·X·O tetrad.G-quadruplex DNA structures can interfere with uracil glycosylase activity in vitro.Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriersDeficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair.Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable LiabilityFormation and processing of DNA damage substrates for the hNEIL enzymes.Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism.Formation and repair of oxidatively generated damage in cellular DNA.A role for the base excision repair enzyme NEIL3 in replication-dependent repair of interstrand DNA cross-links derived from psoralen and abasic sites.8-Oxo-7,8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis.Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress.Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase.NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis.Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response.Light-induced oxidation of the telomeric G4 DNA in complex with Zn(II) tetracarboxymethyl porphyrin.Visualizing the Search for Radiation-damaged DNA Bases in Real Time.8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions.8-Oxo-7,8-dihydro-2'-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA.The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription.A Role for Non-B DNA Forming Sequences in Mediating Microlesions Causing Human Inherited Disease.Human DNA Repair Genes Possess Potential G-Quadruplex Sequences in Their Promoters and 5'-Untranslated Regions.Genetic variation in the NEIL2 DNA glycosylase gene is associated with oxidative DNA damage in BRCA2 mutation carriers.The C-terminal tail of the NEIL1 DNA glycosylase interacts with the human mitochondrial single-stranded DNA binding protein.Case studies on potential G-quadruplex-forming sequences from the bacterial orders Deinococcales and Thermales derived from a survey of published genomesA G-Quadruplex Structure in the Promoter Region of Functions as a Regulatory Element for Gene Expression
P2860
Q26777671-634625BB-A127-493B-BCEE-5EB22A8AF3B1Q33558133-CA2468F4-5F96-4E6B-B5C7-92E5228E9822Q33854259-F711D3FE-7FD2-489A-8917-EBA3BE3385E5Q34505885-D5A1EFF4-3FD0-4FB6-B9CE-2A7D5CAE4270Q36063330-280CA0F4-C3F1-448A-AA2F-C524212735DAQ36337728-482FC8A1-7F0E-4959-814F-A0D9573292D1Q37028770-CD55B6C5-9A1F-4813-AF09-E1CFF5623E1BQ37295507-CB285EB2-6449-48D0-9C03-0BFBB73CFC83Q37395818-E99B3E75-51CE-4A1F-9165-2F972B7F5A0CQ37696021-FC1AFF5E-B348-4847-B23A-1C97BF322300Q38434331-74E79DD7-0F12-4CDF-A55B-743D6C6FA43AQ38943129-7C17A1E2-AAB0-47B4-AB9D-7C09D91179EBQ39018239-DFA5AFB1-D73B-41B5-A636-FBB848E60A19Q39019092-828B3C7C-F6DD-47B0-A76A-CDDA4C5A10ECQ39037391-3FE43072-99AF-439A-A29C-FB4B0392EEC2Q39163453-6E9461A9-3DCC-478F-8D28-6CAF9D69B4A8Q39383987-2086F6A4-AE67-416D-99BB-69E841E1987EQ39638326-0BDC9C6D-E2A4-41F7-B831-256068129593Q41225003-D3ADCD03-3F82-4A36-B44F-3ED26FE1406DQ41712614-DE3B8EB6-1A0A-4010-A3E5-5C3B2EF7C0B1Q41826070-99EA351C-E608-4EF1-BB59-899310F23449Q42116749-C5A37A6D-6498-480D-B93F-37E54268A45EQ42358721-0CBAB601-5AF0-40F1-AF0C-DB6EDD82FB6AQ42683844-991DB78B-97B7-415C-A558-3B24A7E066FEQ46254222-758135A4-FE1E-4DBD-857A-2705470065A5Q46303021-19667293-C630-49C4-8B82-E356B49A0490Q47373966-A91454BC-F156-4451-A91A-ABA42C110E7BQ47902770-2B8CE4FA-FD1A-4B78-88E6-33B78C723356Q48271035-F4F1C8B2-D305-47B6-9537-27E769BF823EQ49569666-C7EE2F7F-6480-4328-82B1-0C7CE884C2D2Q52361367-E21FAB84-1AE9-4F4A-87AC-61735FE324F2Q57794758-7AD5BF87-F80A-4D2D-AA1A-F7CD8911A891Q58753115-C2745F2D-909B-43D9-B726-27F3F03F72D1
P2860
The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The NEIL glycosylases remove o ...... oter quadruplex DNA structures
@ast
The NEIL glycosylases remove o ...... oter quadruplex DNA structures
@en
type
label
The NEIL glycosylases remove o ...... oter quadruplex DNA structures
@ast
The NEIL glycosylases remove o ...... oter quadruplex DNA structures
@en
prefLabel
The NEIL glycosylases remove o ...... oter quadruplex DNA structures
@ast
The NEIL glycosylases remove o ...... oter quadruplex DNA structures
@en
P2093
P2860
P356
P1476
The NEIL glycosylases remove o ...... oter quadruplex DNA structures
@en
P2093
Aaron M Fleming
April M Averill
Cynthia J Burrows
P2860
P304
P356
10.1093/NAR/GKV252
P407
P577
2015-03-26T00:00:00Z