Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.
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De Novo Fragment Design for Drug Discovery and Chemical BiologyWhat is a "DNA-Compatible" Reaction?Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins.DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library SynthesisPhage-displayed macrocyclic glycopeptide libraries.Automated screening for small organic ligands using DNA-encoded chemical libraries.Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial LibrariesDNA-encoded chemical libraries: foundations and applications in lead discovery.Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View.Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries.Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA-Encoded Chemical Library Selections.Combinatorial chemistry in drug discovery.Imaging of carbonic anhydrase IX with an 111In-labeled dual-motif inhibitor.Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell CarcinomaLinker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma.[64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma.Emerging trends in enzyme inhibition by multivalent nanoconstructs.Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors.Design, preparation, and selection of DNA-encoded dynamic librariesPast, Present, and Future: Development of Theranostic Agents Targeting Carbonic Anhydrase IX.DNA-Encoded Chemical Libraries: A Selection System Based On Endowing Organic Compounds with Amplifiable Information.Impact of a Central Scaffold on the Binding Affinity of Fragment Pairs Isolated from DNA-Encoded Self-Assembling Chemical Libraries.Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection.A Specific and Covalent JNK-1 Ligand Selected from an Encoded Self-Assembling Chemical Library.Chemically Defined Antibody- and Small Molecule-Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis.ECBS & ICBS 2015 Joint Meeting: Bringing Chemistry to Life.Cell-surface marker discovery for lung cancer.Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries.Targeted Delivery of Cytotoxic Drugs: Challenges, Opportunities and New Developments.Enhanced Therapeutic Activity of Non-Internalizing Small Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination With Targeted Interleukin-2.DNA-encoded chemical libraries: Achievements and remaining challenges.A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition
P2860
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P2860
Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Dual-display of small molecule ...... cilitates affinity maturation.
@ast
Dual-display of small molecule ...... cilitates affinity maturation.
@en
type
label
Dual-display of small molecule ...... cilitates affinity maturation.
@ast
Dual-display of small molecule ...... cilitates affinity maturation.
@en
prefLabel
Dual-display of small molecule ...... cilitates affinity maturation.
@ast
Dual-display of small molecule ...... cilitates affinity maturation.
@en
P2093
P50
P356
P1433
P1476
Dual-display of small molecule ...... acilitates affinity maturation
@en
P2093
Francesca Pretto
Nikolaus Krall
Petra Schneider
Raphael M Franzini
Willy Decurtins
P2888
P304
P356
10.1038/NCHEM.2158
P577
2015-01-26T00:00:00Z