Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations
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Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53Why mitochondria must fuse to maintain their genome integrityEvolutionary defined role of the mitochondrial DNA in fertility, disease and ageingThe hallmarks of agingThe end of AIDS: HIV infection as a chronic diseaseHIV-1 infection and first line ART induced differential responses in mitochondria from blood lymphocytes and monocytes: the ANRS EP45 "Aging" studyFrailty in HIV: Epidemiology, Biology, Measurement, Interventions, and Research Needs.Age-related changes of mitochondrial transcription factor a expression in rotator cuff degeneration.Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenanceAddressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain.Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals.Aging of the human innate immune system in HIV infection.Questioning the HIV-AIDS Hypothesis: 30 Years of DissentNatural compounds and aging: between autophagy and inflammasome.Dietary algae and HIV/AIDS: proof of concept clinical dataNon-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells.HIV, dementia and antiretroviral drugs: 30 years of an epidemic.Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIVPolymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.Evidence of Subclinical mtDNA Alterations in HIV-Infected Pregnant Women Receiving Combination Antiretroviral Therapy Compared to HIV-Negative Pregnant Women.Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA.Mitochondrial dysfunction in aging: Much progress but many unresolved questions.AZT-induced mitochondrial toxicity: an epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stressMitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults.The genetic pleiotropy of musculoskeletal aging.Thymidine analogues suppress autophagy and adipogenesis in cultured adipocytes.Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging.Impact of age on markers of HIV-1 diseaseSkeletal muscle cellular metabolism in older HIV-infected men.Role of mitochondria in HIV infection and associated metabolic disorders: focus on nonalcoholic fatty liver disease and lipodystrophy syndrome.Mitochondrial DNA deletions in Alzheimer's brains: a reviewOlder HIV-infected patients on antiretroviral therapy have B-cell expansion and attenuated CD4 cell increases with immune activation reduction.Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing.Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.Elevated serum fibroblast growth factor 21 levels correlate with immune recovery but not mitochondrial dysfunction in HIV infection.Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients.In vivo mitochondrial function in HIV-infected persons treated with contemporary anti-retroviral therapy: a magnetic resonance spectroscopy study.High frequency of mitochondrial DNA mutations in HIV-infected treatment-experienced individuals.Mitochondrial toxicity and caspase activation in HIV pregnant women.
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P2860
Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Mitochondrial aging is acceler ...... l expansion of mtDNA mutations
@ast
Mitochondrial aging is acceler ...... l expansion of mtDNA mutations
@en
type
label
Mitochondrial aging is acceler ...... l expansion of mtDNA mutations
@ast
Mitochondrial aging is acceler ...... l expansion of mtDNA mutations
@en
prefLabel
Mitochondrial aging is acceler ...... l expansion of mtDNA mutations
@ast
Mitochondrial aging is acceler ...... l expansion of mtDNA mutations
@en
P2093
P2860
P50
P356
P1433
P1476
Mitochondrial aging is acceler ...... l expansion of mtDNA mutations
@en
P2093
Brendan A I Payne
Charlotte A Hateley
D Ashley Price
P2860
P2888
P304
P356
10.1038/NG.863
P407
P577
2011-06-26T00:00:00Z
P5875
P6179
1044311526