Orexin-1 receptor signaling increases motivation for cocaine-associated cues
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Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep.The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice.Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders.Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways.Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2.Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology.Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner.Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand.Hypocretin/Orexin and Plastic Adaptations Associated with Drug Abuse.Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats.Individual differences in orexin-I receptor modulation of motivation for the opioid remifentanil.Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine.Orexin/hypocretin receptor 1 signaling mediates Pavlovian cue-food conditioning and extinction.A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling.Medications for alcohol use disorders: An overview.Inhibiting subthalamic nucleus decreases cocaine demand and relapse: therapeutic potential.Role of hypocretin/orexin receptor blockade on drug-taking and ultrasonic vocalizations (USVs) associated with low-effort self-administration of cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV) in rats.The hypocretin/orexin system as a target for excessive motivation in alcohol use disorders.Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research.Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia.Recent advances in understanding the roles of hypocretin/orexin in arousal, affect, and motivationDrug Seeking and Relapse: New Evidence of a Role for Orexin and Dynorphin Co-transmission in the Paraventricular Nucleus of the ThalamusParallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons
P2860
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P2860
Orexin-1 receptor signaling increases motivation for cocaine-associated cues
description
2015 nî lūn-bûn
@nan
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
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2015年论文
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name
Orexin-1 receptor signaling increases motivation for cocaine-associated cues
@ast
Orexin-1 receptor signaling increases motivation for cocaine-associated cues
@en
type
label
Orexin-1 receptor signaling increases motivation for cocaine-associated cues
@ast
Orexin-1 receptor signaling increases motivation for cocaine-associated cues
@en
prefLabel
Orexin-1 receptor signaling increases motivation for cocaine-associated cues
@ast
Orexin-1 receptor signaling increases motivation for cocaine-associated cues
@en
P2860
P356
P1476
Orexin-1 receptor signaling increases motivation for cocaine-associated cues
@en
P2093
Gary Aston-Jones
P2860
P304
P356
10.1111/EJN.12866
P407
P577
2015-03-06T00:00:00Z