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Fibrocalcific aortic valve disease: opportunity to understand disease mechanisms using mouse modelsConserved transcriptional regulatory mechanisms in aortic valve development and diseaseGenetics of valvular heart diseaseThe emerging role of GATA transcription factors in development and diseaseCongenital heart disease-causing Gata4 mutation displays functional deficits in vivoMATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosusProtein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve.Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor.Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development.Rare copy number variants contribute to congenital left-sided heart disease.Two heterozygous mutations in NFATC1 in a patient with Tricuspid Atresia.Sequencing of NOTCH1, GATA5, TGFBR1 and TGFBR2 genes in familial cases of bicuspid aortic valve.Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valvesA roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium).Family Based Whole Exome Sequencing Reveals the Multifaceted Role of Notch Signaling in Congenital Heart DiseasePartitioning the heart: mechanisms of cardiac septation and valve developmentGATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiationEndocardial Brg1 disruption illustrates the developmental origins of semilunar valve disease.Endothelial Gata5 transcription factor regulates blood pressure.Isolation of murine valve endothelial cellsBidirectional Translation in Cardiovascular Calcification.Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract.The pathology and pathobiology of bicuspid aortic valve: State of the art and novel research perspectives.The genetic and molecular basis of bicuspid aortic valve associated thoracic aortopathy: a link to phenotype heterogeneityNfatc1 directs the endocardial progenitor cells to make heart valve primordium.Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation.Normal and abnormal development of the aortic wall and valve: correlation with clinical entities.Review of molecular and mechanical interactions in the aortic valve and aorta: implications for the shared pathogenesis of aortic valve disease and aortopathy.Heart Valve Biomechanics and Underlying MechanobiologyKLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.Genetic basis of aortic valvular disease.GATA5 mutation homozygosity linked to a double outlet right ventricle phenotype in a Lebanese patient.Aortic assessment of bicuspid aortic valve patients and their first-degree relatives.A novel nonsense mutation in NPHS1: is aortic stenosis associated with congenital nephropathy?Genetic Bases of Bicuspid Aortic Valve: The Contribution of Traditional and High-Throughput Sequencing Approaches on Research and Diagnosis.Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves.Novel and functional DNA sequence variants within the GATA5 gene promoter in ventricular septal defects.Pathogenic Mechanisms of Bicuspid Aortic Valve Aortopathy.Genetic insights into bicuspid aortic valve formation.Growth and maturation of heart valves leads to changes in endothelial cell distribution, impaired function, decreased metabolism and reduced cell proliferation.
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Loss of Gata5 in mice leads to bicuspid aortic valve.
@ast
Loss of Gata5 in mice leads to bicuspid aortic valve.
@en
type
label
Loss of Gata5 in mice leads to bicuspid aortic valve.
@ast
Loss of Gata5 in mice leads to bicuspid aortic valve.
@en
prefLabel
Loss of Gata5 in mice leads to bicuspid aortic valve.
@ast
Loss of Gata5 in mice leads to bicuspid aortic valve.
@en
P2860
P356
P1476
Loss of Gata5 in mice leads to bicuspid aortic valve.
@en
P2093
Brigitte Laforest
Gregor Andelfinger
P2860
P304
P356
10.1172/JCI44555
P407
P50
P577
2011-07-01T00:00:00Z