Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor
about
Modulation of neuronal signal transduction and memory formation by synaptic zincRole of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmissionSNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitroDevelopment and regulation of chloride homeostasis in the central nervous systemZinc in the Glutamatergic Theory of DepressionCurrent view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc.Enhanced susceptibility to spontaneous seizures of noda epileptic rats by loss of synaptic zn(2+)Nitric oxide signaling modulates synaptic inhibition in the superior paraolivary nucleus (SPN) via cGMP-dependent suppression of KCC2.Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis.Regulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor, mZnR/GPR39.Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemiaChloride extrusion enhancers as novel therapeutics for neurological diseasesZinc: indications in brain disorders.A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampusEngagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic painN-Cadherin-mediated cell adhesion is regulated by extracellular Zn(2+).The neurophysiology and pathology of brain zinc.Microglia disrupt mesolimbic reward circuitry in chronic pain.Synaptic release and extracellular actions of Zn2+ limit propagation of spreading depression and related events in vitro and in vivoHomeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents.Distinctive hippocampal zinc distribution patterns following stress exposure in an animal model of PTSD.Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine.Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis.Zinc and the aging brainThe role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease.K-Cl cotransporter KCC2--a moonlighting protein in excitatory and inhibitory synapse development and function.The K(+)-Cl(-) Cotransporter KCC2 and Chloride Homeostasis: Potential Therapeutic Target in Acute Central Nervous System Injury.Regulation of neuronal chloride homeostasis by neuromodulators.Amyloid β attenuates metabotropic zinc sensing receptor, mZnR/GPR39, dependent Ca2+ , ERK1/2 and Clusterin signaling in neurons.Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.The Zn2+-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl- absorption, via basolateral KCC1, and reduces fluid loss.The ZnR/GPR39 interacts with the CaSR to enhance signaling in prostate and salivary epithelia.Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors.Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39).The Role of K(+)-Cl(-)-Cotransporter-2 in Neuropathic Pain.K+-Cl- co-transporter 2 (KCC2) - a membrane trafficking perspective.Parallel in vivo and in vitro transcriptomics analysis reveals calcium and zinc signalling in the brain as sensitive targets of HBCD neurotoxicity.
P2860
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P2860
Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Upregulation of KCC2 activity ...... on via the mZnR/GPR39 receptor
@ast
Upregulation of KCC2 activity ...... on via the mZnR/GPR39 receptor
@en
type
label
Upregulation of KCC2 activity ...... on via the mZnR/GPR39 receptor
@ast
Upregulation of KCC2 activity ...... on via the mZnR/GPR39 receptor
@en
prefLabel
Upregulation of KCC2 activity ...... on via the mZnR/GPR39 receptor
@ast
Upregulation of KCC2 activity ...... on via the mZnR/GPR39 receptor
@en
P2093
P2860
P1476
Upregulation of KCC2 activity ...... on via the mZnR/GPR39 receptor
@en
P2093
David Gilad
Ehud Chorin
Elias Aizenman
Israel Sekler
Michal Hershfinkel
Ofir Vinograd
Sharon Herrmann
P2860
P304
12916-12926
P356
10.1523/JNEUROSCI.2205-11.2011
P407
P577
2011-09-01T00:00:00Z