HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
about
Utility of Induced Pluripotent Stem Cells for the Study and Treatment of Genetic Diseases: Focus on Childhood Neurological DisordersDominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural CellsHuntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathwayInduced Pluripotent Stem Cells in Huntington's Disease: Disease Modeling and the Potential for Cell-Based Therapy.iPSC-based drug screening for Huntington's disease.Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells.Linking adult hippocampal neurogenesis with human physiology and disease.Huntington Disease as a Neurodevelopmental Disorder and Early Signs of the Disease in Stem Cells.Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons.Modeling simple repeat expansion diseases with iPSC technology.Induced Pluripotent Stem Cells in Huntington's Disease Research: Progress and Opportunity.Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration.Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice.An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes.Optimization of trans-Splicing for Huntington's Disease RNA Therapy.Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.Tetracycline-Inducible and Reversible Stable Gene Expression in Human iPSC-Derived Neural Progenitors and in the Postnatal Mouse Brain.FOXOs modulate proteasome activity in human-induced pluripotent stem cells of Huntington's disease and their derived neural cells.Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes.Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9.Representing Diversity in the Dish: Using Patient-Derived in Vitro Models to Recreate the Heterogeneity of Neurological Disease.Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development.Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.
P2860
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P2860
HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
HD iPSC-derived neural progeni ...... wal due to glutamate toxicity.
@ast
HD iPSC-derived neural progeni ...... wal due to glutamate toxicity.
@en
type
label
HD iPSC-derived neural progeni ...... wal due to glutamate toxicity.
@ast
HD iPSC-derived neural progeni ...... wal due to glutamate toxicity.
@en
prefLabel
HD iPSC-derived neural progeni ...... wal due to glutamate toxicity.
@ast
HD iPSC-derived neural progeni ...... wal due to glutamate toxicity.
@en
P2093
P2860
P356
P1476
HD iPSC-derived neural progeni ...... wal due to glutamate toxicity.
@en
P2093
Amber L Southwell
Anais Sahabian
Berhan Mandefro
Clive N Svendsen
Colton Tom
Crystal N Doty
Dhruv Sareen
Jamshid Arjomand
Jasmine Saeedian
Lindsay Lenaeus
P2860
P304
P356
10.1093/HMG/DDV080
P577
2015-03-03T00:00:00Z