p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. - Wikidata - awgldk - TriplyDB

p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer.

p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer.

http://www.wikidata.org/entity/Q35588555

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Cell Division Cycle 6 Promotes Mitotic Slippage and Contributes to Drug Resistance in Paclitaxel-Treated Cancer Cells Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET/CT, detected by cDNA microarray, predicts high-risk patients with primary breast cancer.mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia.A study of association between expression of hOGG1, VDAC1, HK-2 and cervical carcinoma.Integrated microRNA and mRNA transcriptome sequencing reveals the potential roles of miRNAs in stage I endometrioid endometrial carcinoma Chromogenic in situ hybridization and p16/Ki67 dual staining on formalin-fixed paraffin-embedded cervical specimens: correlation with HPV-DNA test, E6/E7 mRNA test, and potential clinical applications.Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination.Diagnostic value of MCM2 immunocytochemical staining in cervical lesions and its relationship with HPV infection.The Role of Proteomics in the Diagnosis and Treatment of Women's Cancers: Current Trends in Technology and Future Opportunities Biomarkers of cervical dysplasia and carcinoma Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis Network Topologies Decoding Cervical Cancer.Stratification of HPV-induced cervical pathology using the virally encoded molecular marker E4 in combination with p16 or MCM Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCFCdc4 recognition in Saccharomyces cerevisiae.Our approach to squamous intraepithelial lesions of the uterine cervix The Utility of p16INK4a and Ki-67 as a Conjunctive Tool in Uterine Cervical Lesions.Molecular profiling of cervical neoplasia.Immunohistochemical detection of p16INK4a in dysplastic lesions of the oral cavity.Multiple biomarkers in molecular oncology. I. Molecular diagnostics applications in cervical cancer detection.Differential gene expression between skin and cervix induced by the E7 oncoprotein in a transgenic mouse model New technologies for cervical cancer screening Gene discovery in cervical cancer : towards diagnostic and therapeutic biomarkers.Expression of the p16 and Ki-67 in relation to the grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection.Cancer biomarkers: are we ready for the prime time?p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis.Development of biomarker panel to predict, prevent and create treatments tailored to the persons with human papillomavirus-induced cervical precancerous lesions Testing for human papillomavirus in cervical cancer screening: a review of indications and methodology.Urothelial carcinoma with prominent squamous differentiation in the setting of neurogenic bladder: role of human papillomavirus infection.Factors influencing decisions about surgical treatment of cervical precancerous lesions.Deregulated expression of Cdc6 as BCR/ABL-dependent survival factor in chronic myeloid leukemia cells.Cdc6 expression is induced by HPV16 E6 and E7 oncogenes and represses E-cadherin expression.Manipulation of the innate immune response by human papillomaviruses.DNA Oncogenic Virus-Induced Oxidative Stress, Genomic Damage, and Aberrant Epigenetic Alterations Correlation of p16(INK4A) expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells.HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4A.Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation.Mast cells dysregulate apoptotic and cell cycle genes in mucosal squamous cell carcinoma.Oncogenic activity of Cdc6 through repression of the INK4/ARF locus.Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions.

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P2860

p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer.

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A G Killalea

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P2860

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa

Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F

Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer.

Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.

Minichromosome maintenance proteins as biological markers of dysplasia and malignancy.

Eukaryotic DNA replication: from pre-replication complex to initiation complex.

Analysis of Cdc6 function in the assembly of mammalian prereplication complexes

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