Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis - Wikidata - awgldk - TriplyDB

Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis

Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis

http://www.wikidata.org/entity/Q35598474

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Bedaquiline for the treatment of multidrug-resistant tuberculosis: great promise or disappointment?Antituberculosis therapy for 2012 and beyond Immunogenicity without Efficacy of an Adenoviral Tuberculosis Vaccine in a Stringent Mouse Model for Immunotherapy during Treatment Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide Unravelling the Secrets of Mycobacterial Cidality through the Lens of Antisense Pipeline of drugs for related diseases: tuberculosis Mechanisms of Pyrazinamide Action and Resistance Integrated microfluidic card with TaqMan probes and high-resolution melt analysis to detect tuberculosis drug resistance mutations across 10 genes.Recent advances in tuberculosis: New drugs and treatment regimens.Pyrazinamide susceptibility testing of Mycobacterium tuberculosis by high resolution melt analysis.Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models Novel regimens identified in mice for treatment of latent tuberculosis infection in contacts of patients with multidrug-resistant tuberculosis Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas A Review of the Evidence for Using Bedaquiline (TMC207) to Treat Multi-Drug Resistant Tuberculosis New drugs to treat multidrug-resistant tuberculosis: the case for bedaquiline A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging.Contribution of the nitroimidazoles PA-824 and TBA-354 to the activity of novel regimens in murine models of tuberculosis.Radioiodinated DPA-713 imaging correlates with bactericidal activity of tuberculosis treatments in mice.Counting pyrazinamide in regimens for multidrug-resistant tuberculosis Pharmacokinetics and pharmacodynamics of clofazimine in a mouse model of tuberculosis.Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives.Mode of Action of Clofazimine and Combination Therapy with Benzothiazinones against Mycobacterium tuberculosis Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection model In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment Mutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosis Sterilizing activities of novel combinations lacking first- and second-line drugs in a murine model of tuberculosis.Epidemiologic Correlates of Pyrazinamide-Resistant Mycobacterium tuberculosis in New York City.Epidemiology of pyrazinamide-resistant tuberculosis in the United States, 1999-2009 Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis.Dose-ranging comparison of rifampin and rifapentine in two pathologically distinct murine models of tuberculosis Pyrazinamide may improve fluoroquinolone-based treatment of multidrug-resistant tuberculosis.Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis A physiologically based pharmacokinetic model of rifampin in mice.Direct Susceptibility Testing of Mycobacterium tuberculosis for Pyrazinamide by Use of the Bactec MGIT 960 System.Clofazimine Contributes Sustained Antimicrobial Activity after Treatment Cessation in a Mouse Model of Tuberculosis Chemotherapy.Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice.Adjuvant host-directed therapy with types 3 and 5 but not type 4 phosphodiesterase inhibitors shortens the duration of tuberculosis treatment High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis.Potent rifamycin-sparing regimen cures guinea pig tuberculosis as rapidly as the standard regimen Contribution of moxifloxacin or levofloxacin in second-line regimens with or without continuation of pyrazinamide in murine tuberculosis.

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P2860

Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis

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Antimicrobial Agents and Chemotherapy

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Sterilizing activity of novel ...... a murine model of tuberculosis

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Charles A Peloquin

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Dinesh Taylor

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Eric L Nuermberger

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Kathy N Williams

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Khisimuzi E Mdluli

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Koen Andries

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Rokeya Tasneen

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Si-Yang Li

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P2860

OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice

Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model

The diarylquinoline TMC207 for multidrug-resistant tuberculosis

Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis. In vitro, intracellular, and in vivo studies

Effectiveness of various antimicrobial agents against Mycobacterium avium complex in the beige mouse model

Antituberculosis activities of clofazimine and its new analogs B4154 and B4157

Sterilizing activity of second-line regimens containing TMC207 in a murine model of tuberculosis

Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

Bactericidal activity of the nitroimidazopyran PA-824 in a murine model of tuberculosis.

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5485-5492

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10.1128/AAC.05293-11

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12

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21930883

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Akafuba bulwadde

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3232786

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