Progranulin: a growth factor, a novel TNFR ligand and a drug target
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The role of progranulin in diabetes and kidney diseaseThe role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis.PGRN induces impaired insulin sensitivity and defective autophagy in hepatic insulin resistanceTumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer.Establishment of a surgically-induced model in mice to investigate the protective role of progranulin in osteoarthritis.Implication of progranulin and C1q/TNF-related protein-3 (CTRP3) on inflammation and atherosclerosis in subjects with or without metabolic syndromeProgranulin protects vascular endothelium against atherosclerotic inflammatory reaction via Akt/eNOS and nuclear factor-κB pathwaysProgranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity.The role of PGRN in musculoskeletal development and disease.Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes.GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation.Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner.Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2/Akt and ERK signaling pathways.Insights into the role of progranulin in immunity, infection, and inflammation.Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFα signaling.Moxibustion upregulates hippocampal progranulin expressionNew discovery rarely runs smooth: an update on progranulin/TNFR interactionsReview: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling.The role of progranulin in arthritis.The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling.A solid-phase assay for studying direct binding of progranulin to TNFR and progranulin antagonism of TNF/TNFR interactions.Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling.Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone-related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor.Can existing drugs approved for other indications retard renal function decline in patients with type 1 diabetes and nephropathy?Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice.Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4⁺ Foxp3⁺ regulatory T cells.Serum progranulin levels in Hispanic rheumatoid arthritis patients treated with TNF antagonists: a prospective, observational study.Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models.Progranulin derived engineered protein Atsttrin suppresses TNF-α-mediated inflammation in intervertebral disc degenerative disease.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Association of polymorphisms in TNF and GRN genes with ankylosing spondylitis in a Chinese Han population.Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease.Release of transgenic progranulin from a living hyaline cartilage graft model: An in vitro evaluation on anti-inflammation.Adipokines and inflammation: is it a question of weight?Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis-like skin inflammation.Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway.
P2860
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P2860
Progranulin: a growth factor, a novel TNFR ligand and a drug target
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Progranulin: a growth factor, a novel TNFR ligand and a drug target
@ast
Progranulin: a growth factor, a novel TNFR ligand and a drug target
@en
type
label
Progranulin: a growth factor, a novel TNFR ligand and a drug target
@ast
Progranulin: a growth factor, a novel TNFR ligand and a drug target
@en
prefLabel
Progranulin: a growth factor, a novel TNFR ligand and a drug target
@ast
Progranulin: a growth factor, a novel TNFR ligand and a drug target
@en
P2860
P1476
Progranulin: a growth factor, a novel TNFR ligand and a drug target
@en
P2093
Xavier Bosch
P2860
P304
P356
10.1016/J.PHARMTHERA.2011.10.003
P50
P577
2011-10-08T00:00:00Z