MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells.
about
Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTORStem cell guidance through the mechanistic target of rapamycinErythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life ExpectancyNanoscale characterization of PM2.5 airborne pollutants reveals high adhesiveness and aggregation capability of soot particlesMicrotubules and their role in cellular stress in cancerDesign, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agentsMonascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy.Combination erlotinib-cisplatin and Atg3-mediated autophagy in erlotinib resistant lung cancer.Taking aim at Alzheimer's disease through the mammalian target of rapamycinEffect of autophagy inhibition on chemotherapy-induced apoptosis in A549 lung cancer cells.Autophagy as a modulator and target in prostate cancer.Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways.Role of autophagy in the ω-3 long chain polyunsaturated fatty acid-induced death of lung cancer A549 cells.Curcumin: updated molecular mechanisms and intervention targets in human lung cancer.SD118-xanthocillin X (1), a novel marine agent extracted from Penicillium commune, induces autophagy through the inhibition of the MEK/ERK pathway.Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents.Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative ActivityRegeneration in the nervous system with erythropoietinA Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.Novel directions for diabetes mellitus drug discoveryTargeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapySKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway.Synergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma.Retigeric acid B-induced mitophagy by oxidative stress attenuates cell death against prostate cancer cells in vitro.Benzyl isothiocyanate induces protective autophagy in human lung cancer cells through an endoplasmic reticulum stress-mediated mechanism.Autophagy and ionizing radiation in tumors: the "survive or not survive" dilemma.Autophagy and cancer: taking the 'toxic' out of cytotoxics.Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders.A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression.Autophagy in 5-Fluorouracil Therapy in Gastrointestinal Cancer: Trends and Challenges.βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells.Neferine induces autophagy of human ovarian cancer cells via p38 MAPK/ JNK activation.The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastomaEmerging treatment using tubulin inhibitors in advanced non-small cell lung cancer.Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells.Ubenimex enhances the radiosensitivity of renal cell carcinoma cells by inducing autophagic cell death.Involvement of autophagy in the outcome of mitotic catastrophe.A novel multikinase inhibitor R8 exhibits potent inhibition on cancer cells through both apoptosis and autophagic cell death.Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs.Design, Synthesis, and Photophysical Properties of Pyrroloquinoline-Based Compounds Showing Strong Blue Fluorescence as Potential Dyes for Biomedical Applications.
P2860
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P2860
MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
MG-2477, a new tubulin inhibit ...... layed apoptosis in A549 cells.
@ast
MG-2477, a new tubulin inhibit ...... layed apoptosis in A549 cells.
@en
type
label
MG-2477, a new tubulin inhibit ...... layed apoptosis in A549 cells.
@ast
MG-2477, a new tubulin inhibit ...... layed apoptosis in A549 cells.
@en
prefLabel
MG-2477, a new tubulin inhibit ...... layed apoptosis in A549 cells.
@ast
MG-2477, a new tubulin inhibit ...... layed apoptosis in A549 cells.
@en
P2093
P2860
P50
P1476
MG-2477, a new tubulin inhibit ...... layed apoptosis in A549 cells.
@en
P2093
Ernest Hamel
Maria Grazia Ferlin
Paola Brun
Roberta Bortolozzi
P2860
P356
10.1016/J.BCP.2011.09.017
P407
P577
2011-09-22T00:00:00Z