Adenomatous-polyposis-coli-ProteinApc,_wnt_signaling_pathway_regulatorAPC_(gen)APC_(%D9%BE%D8%B1%D9%88%D8%AA%D8%A6%DB%8C%D9%86)Adenomatosis_polyposis_coliAPC_(prot%C3%A9ine)Adenomatous_Polyposis_ColiAPC_(gen)Adenomatozis_polipozis_koliAPC_(%D0%B3%D0%B5%D0%BD)%D8%BA%D8%AF%D9%88%D9%85%D8%A7%D8%A6%DB%8C_%D8%B3%D9%84%DB%8C%D9%84%D8%AA_%D9%82%D9%88%D9%84%D9%88%D9%86%DB%8CQ356062
about
sameAs
P688
Regulation and function of the interaction between the APC tumour suppressor protein and EB1Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasmBinding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylationA role for the Adenomatous Polyposis Coli protein in chromosome segregationPin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APCAssociation and regulation of casein kinase 2 activity by adenomatous polyposis coli proteinDifferential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1Subcellular distribution of Wnt pathway proteins in normal and neoplastic colonErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNAThe tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phaseAPC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulationBinding of GSK3beta to the APC-beta-catenin complex and regulation of complex assemblyHuman scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coliThe APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobinAn EB1-binding motif acts as a microtubule tip localization signalAsef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migrationDownregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 betaWnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradationNuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferationAssociation of the APC gene product with beta-cateninA novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signalsE-cadherin and APC compete for the interaction with beta-catenin and the cytoskeletonThe adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functionsLack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stabilityPutative tumor suppressor EDD interacts with and up-regulates APCThe third 20 amino acid repeat is the tightest binding site of APC for beta-cateninInsulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein.Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signalingExtensive metabolic disorders are present in APC(min) tumorigenesis mice.
P921
Q50256112-B8F5F4C5-05E2-4FD5-9264-D2FCC46E676BQ50256113-6C410916-B568-4F4F-A1DA-9CC6F1A2F40AQ50256128-3231DFFF-2630-41AD-86C1-C9B98BA1EA74Q50273544-ABAD71D2-2555-4C42-A19A-80DFB2F5C9E7Q50273547-B390FE6B-F9EF-43E4-938B-A77DEA79BE9EQ50297388-DA69E1E6-6289-4395-AB2F-203A7F47557AQ50297388-ED9C71CF-3683-4389-9876-FA05B9203A72Q50298706-5CE8DB34-15D5-4B62-B9C3-7F37B6171494Q50298764-803EC911-0135-4E54-9B7E-D11989578290
P527
Q22253944-52185A70-BFED-4CD1-9191-46CD3BA81FF4Q24290419-22472D87-EEC3-4348-85A7-79510B56DCE7Q24290797-F7171B8F-284F-4072-8845-BA2F515194D9Q24291074-607450B7-021B-4315-B2AF-EC1ED1AFB820Q24291638-C1E28579-38DA-4D67-A612-D9EE7691F5CBQ24295108-25359E68-E946-41DE-9F02-9460CD50FE0FQ24298632-42BD662E-7492-4816-A4A0-3C3765E290EDQ24299973-E96AE40E-B23A-4902-B56F-D5D895DD83ECQ24302369-2D16086D-4A0F-45BC-9181-4989F88BBDC9Q24305132-CFC45670-F369-466B-AE14-0BF949EC18C8Q24310213-0F3DCC0C-01F3-47C0-9098-3EFEB1362EDCQ24311271-EDEDE29D-EC26-4E70-A0E8-8C782E29591FQ24312910-AD49042F-72AA-44CF-A870-843CC8C5A4F3Q24317012-111CD46D-07FE-4E53-98EB-77E2E059AAA2Q24317231-5E2C07C9-3092-407C-95CB-F588CB3435BBQ24317437-CC98637C-08FA-4969-B96E-ED9D68D2F928Q24317786-4D4445F5-E1F8-4A03-B141-8E13A2E856F0Q24319688-CED2EBCD-DBA8-499D-A4A6-ECF550B7F992Q24319714-9678FBB9-B231-45C8-B550-26EE28F64FDEQ24319918-329FDB78-B5C1-4B65-96BD-9688B22FAE6CQ24322359-81A249DE-0B35-48A2-8C08-427FF8C77948Q24324809-C7532E8A-EC1D-4B42-9B7F-018FD1971E26Q24336494-052599B0-54D7-417C-A38E-2D34029D2961Q24336996-3AFAC53A-3D90-4077-9806-29A8025007BEQ24338380-686D3D34-6F60-4EAF-A841-7EE9061B5E7EQ28115427-D9C5A194-4946-4110-97E1-CFFD8E297F76Q28244270-F41EF235-EC46-4102-A589-B407E13B6573Q28910200-919DCFD2-47B1-4C59-9ED5-3FF2F104397BQ35011212-EFCA745F-575D-43BA-B1E4-D9E26025CD13Q52881858-BAB700E6-ADA2-4B2D-BA7B-F38A8ADEEF2A
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in APC, WNT signaling pathway regulator
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
APC (gen)
@es
APC (gen)
@pl
APC (ген)
@uk
APC (پروتئین)
@fa
APC regulator of WNT signaling pathway
@en
APC
@fr
APC, WNT signaling pathway regulator
@nl
Adenomatosis polyposis coli
@fi
Adenomatous Polyposis Coli
@it
Adenomatous-polyposis-coli-Protein
@de
type
label
APC (gen)
@es
APC (gen)
@pl
APC (ген)
@uk
APC (پروتئین)
@fa
APC regulator of WNT signaling pathway
@en
APC
@fr
APC, WNT signaling pathway regulator
@nl
Adenomatosis polyposis coli
@fi
Adenomatous Polyposis Coli
@it
Adenomatous-polyposis-coli-Protein
@de
altLabel
APC
@en
APC
@ur
APC, WNT signaling pathway regulator
@en
Adenomatosis polyposis coli
@ur
Adenomatous Polyposis of the Colon
@de
Adenomatous polyposis coli-Protein
@de
Gen APC
@pl
WNT signaling pathway regulator
@en
adenomatosis polyposis coli tumor suppressor
@en
adenomatous polyposis coli (APC)
@en
prefLabel
APC (gen)
@es
APC (gen)
@pl
APC (ген)
@uk
APC (پروتئین)
@fa
APC regulator of WNT signaling pathway
@en
APC
@fr
APC, WNT signaling pathway regulator
@nl
Adenomatosis polyposis coli
@fi
Adenomatous Polyposis Coli
@it
Adenomatous-polyposis-coli-Protein
@de
P361
P527
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P2888
P31
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P361
P373
Adenomatous polyposis coli protein
P527
P637
NP_001120982
NP_001120983
NP_001341824
NP_001341825
NP_001341826
NP_001341827
NP_001341828
NP_001341829
NP_001341830
P638
P646
P680
P681
P682
P702
P703
P705
ENSP00000257430
ENSP00000423224
ENSP00000423828
ENSP00000424265
ENSP00000426541
ENSP00000427089
ENSP00000473355
ENSP00000481752
ENSP00000484935