Metabolic signature identifies novel targets for drug resistance in multiple myeloma.
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Hypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic axis in multiple myelomaPharmacogenomics and chemical library screens reveal a novel SCFSKP2 inhibitor that overcomes Bortezomib resistance in multiple myeloma.Homoharringtonine delivered by high proportion PEG of long- circulating liposomes inhibits RPMI8226 multiple myeloma cells in vitro and in vivoNavigating the bone marrow niche: translational insights and cancer-driven dysfunction.Effects of survivin on FVADT chemotherapy for refractory multiple myeloma.Potential role of exosome-associated microRNA panels and in vivo environment to predict drug resistance for patients with multiple myeloma.Proteomic identification of the lactate dehydrogenase A in a radioresistant prostate cancer xenograft mouse model for improving radiotherapy.Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival.Extracellular matrix protein Reelin promotes myeloma progression by facilitating tumor cell proliferation and glycolysis.Targeting of cell metabolism in human acute myeloid leukemia--more than targeting of isocitrate dehydrogenase mutations and PI3K/AKT/mTOR signaling?Microvesicles derived from normal and multiple myeloma bone marrow mesenchymal stem cells differentially modulate myeloma cells' phenotype and translation initiation.PEGylated long-circulating liposomes deliver homoharringtonine to suppress multiple myeloma cancer stem cellsCell intrinsic and extrinsic regulation of leukemia cell metabolism.A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity.Efficacy of the HSP70 inhibitor PET-16 in multiple myeloma.KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models.The hypoxia signalling pathway in haematological malignancies.Drug resistance in hematologic malignancies: induction mechanisms, genetics, and therapeutics.Bortezomib resistance in multiple myeloma is associated with increased serine synthesis.Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts.Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis.De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition.Evolutionary biology of high-risk multiple myeloma.Tris DBA palladium overcomes hypoxia-mediated drug resistance in multiple myeloma.Hypoxia favors the generation of human plasma cells.Perturbation-response genes reveal signaling footprints in cancer gene expression.Targeted knockdown of DJ-1 induces multiple myeloma cell death via KLF6 upregulation.The bone-marrow niche in MDS and MGUS: implications for AML and MM.CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes.Metabolic Features of Multiple Myeloma.Elevated lactate dehydrogenase (LDH) can be a marker of immune suppression in cancer: Interplay between hematologic and solid neoplastic clones and their microenvironments.The role of HIF-1α in chemo-/radioresistant tumors.A set of cancer stem cell homing peptides associating with the glycan moieties of glycosphingolipids.Pterostilbene inhibits nutrient metabolism and induces apoptosis through AMPK activation in multiple myeloma cellsPGC1β regulates multiple myeloma tumor growth through LDHA-mediated glycolytic metabolismThe metabolomic plasma profile of myeloma patients is considerably different from healthy subjects and reveals potential new therapeutic targetsThe Influence of Metabolism on Drug Response in Cancer
P2860
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P2860
Metabolic signature identifies novel targets for drug resistance in multiple myeloma.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Metabolic signature identifies novel targets for drug resistance in multiple myeloma.
@ast
Metabolic signature identifies novel targets for drug resistance in multiple myeloma.
@en
type
label
Metabolic signature identifies novel targets for drug resistance in multiple myeloma.
@ast
Metabolic signature identifies novel targets for drug resistance in multiple myeloma.
@en
prefLabel
Metabolic signature identifies novel targets for drug resistance in multiple myeloma.
@ast
Metabolic signature identifies novel targets for drug resistance in multiple myeloma.
@en
P2093
P2860
P50
P1433
P1476
Metabolic signature identifies novel targets for drug resistance in multiple myeloma.
@en
P2093
Alec C Kimmelman
Daisy Huynh
Irene M Ghobrial
John M Asara
Michele Moschetta
Yosra Aljawai
Yuji Mishima
P2860
P304
P356
10.1158/0008-5472.CAN-14-3400
P407
P577
2015-03-13T00:00:00Z