Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA.
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Translating the epitranscriptomeRNA-Based Vaccines in Cancer ImmunotherapyRecombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyondMessenger RNA-based vaccines: progress, challenges, applicationsRNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune SignalingFeeder-free derivation of human induced pluripotent stem cells with messenger RNAThe notorious R.N.A. in the spotlight - drug or target for the treatment of diseaseN1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome densityUnderstanding RNA modifications: the promises and technological bottlenecks of the 'epitranscriptome'.Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA-protein correlations at the level of single cells.Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine.Identification of Cyclobutane Pyrimidine Dimer-Responsive Genes Using UVB-Irradiated Human Keratinocytes Transfected with In Vitro-Synthesized Photolyase mRNA.mRNA leapfrogs DNA to show promise for therapeutic gene transferNucleofection induces transient eIF2α phosphorylation by GCN2 and PERK.Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin.mRNA-Mediated Gene Supplementation of Toll-Like Receptors as Treatment Strategy for Asthma In Vivo.Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes.Modified mRNA as an alternative to plasmid DNA (pDNA) for transcript replacement and vaccination therapy.Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy.Developing mRNA-vaccine technologies.Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals.Augmentation of epithelial resistance to invading bacteria by using mRNA transfections.Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: a new approach with future therapeutic potentialEfficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo.Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge.The ReNAissanCe of mRNA-based cancer therapy.mRNA transcript therapy.Enhancing the pharmacokinetic/pharmacodynamic properties of therapeutic nucleotides using lipid nanoparticle systems.Genetic medicines for CF: Hype versus reality.Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity.Concise Review: Application of In Vitro Transcribed Messenger RNA for Cellular Engineering and Reprogramming: Progress and Challenges.Viral and Synthetic RNA Vector Technologies and Applications.V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting CellsmRNA: Fulfilling the Promise of Gene Therapy.Evaluation of RNA Amplification Methods to Improve DC Immunotherapy Antigen Presentation and Immune ResponseMeasuring the Adjuvant Activity of RNA Vaccines.Nucleoside Modified mRNA Vaccines for Infectious Diseases.Synthetic mRNA: Production, Introduction into Cells, and Physiological Consequences.Reprogramming of Pancreatic Exocrine Cells AR42J Into Insulin-producing Cells Using mRNAs for Pdx1, Ngn3, and MafA Transcription Factors.Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications.
P2860
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P2860
Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Generating the optimal mRNA fo ...... dified, protein-encoding mRNA.
@ast
Generating the optimal mRNA fo ...... dified, protein-encoding mRNA.
@en
type
label
Generating the optimal mRNA fo ...... dified, protein-encoding mRNA.
@ast
Generating the optimal mRNA fo ...... dified, protein-encoding mRNA.
@en
prefLabel
Generating the optimal mRNA fo ...... dified, protein-encoding mRNA.
@ast
Generating the optimal mRNA fo ...... dified, protein-encoding mRNA.
@en
P2093
P2860
P356
P1476
Generating the optimal mRNA fo ...... dified, protein-encoding mRNA.
@en
P2093
Drew Weissman
Hiromi Muramatsu
János Ludwig
Katalin Karikó
P2860
P356
10.1093/NAR/GKR695
P407
P577
2011-09-02T00:00:00Z