about
The CK1 Family: Contribution to Cellular Stress Response and Its Role in CarcinogenesisPhosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective functionCdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiationCharting the molecular network of the drug target Bcr-Ablc-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's diseaseAllosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1Phosphorylation of human oxoguanine DNA glycosylase (alpha-OGG1) modulates its functionRegulation of mitochondrial functions by protein phosphorylation and dephosphorylationMultifunctional Abl kinases in health and diseaseCritical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodelingThe growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABLLow doses of imatinib induce myelopoiesis and enhance host anti-microbial immunityNMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiensA potent and highly specific FN3 monobody inhibitor of the Abl SH2 domainTargeting the SH2-Kinase Interface in Bcr-Abl Inhibits LeukemogenesisCrystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activityProtein Kinases and Parkinson's Diseasec-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's DiseaseIdentification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinasesRole of ABL family kinases in cancer: from leukaemia to solid tumoursA Src-like inactive conformation in the abl tyrosine kinase domainOptimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designingc-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expressionThe SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motionFluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase FunctionTowards a Molecular Understanding of the Link between Imatinib Resistance and Kinase Conformational DynamicsAbelson kinase acts as a robust, multifunctional scaffold in regulating embryonic morphogenesis.Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAblc-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in SolutionParallel Chemical Protein Synthesis on a Surface Enables the Rapid Analysis of the Phosphoregulation of SH3 Domains.Defying c-Abl signaling circuits through small allosteric compounds.Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.Avian influenza viruses inhibit the major cellular signalling integrator c-Abl.NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors.Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-capIntramolecular dynamics within the N-Cap-SH3-SH2 regulatory unit of the c-Abl tyrosine kinase reveal targeting to the cellular membranePartial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitorsProteome-wide detection of Abl1 SH3-binding peptides by integrating computational prediction and peptide microarray.Abl promotes cadherin-dependent adhesion and signaling in myoblasts.
P2860
Q21129297-DEAE2417-37C3-4B1A-AE16-8D808523A0A6Q24298958-C088B0D4-8F8A-440F-A4CF-485259CFBAC3Q24314378-C6B16867-9062-4D9E-A924-C3B29BC734C6Q24317707-420B4904-6093-49F0-AD36-25E8CF64AED0Q24318974-4BED8E51-9C9E-4B63-8ADC-83C2FD97A39AQ24321968-1D2BF8DF-6C6C-4812-A3F0-DCC61D13EB4DQ24810298-CA814B06-7E95-4325-B4AE-A457888D2F3EQ26752880-D11FC20F-F1AA-46AD-80B0-95BCF0379A23Q26771277-39187899-95F8-42C8-A2CA-0A54D2122F4FQ26777713-C4B622A8-E74C-4B84-9E4F-0C53F5B89DFFQ26866312-A2C6E928-5541-4368-BCE2-1CB943479D5AQ27320733-C98FDE49-CFEE-4496-AEC8-47871759F6ECQ27658972-6F8C05DF-5103-4815-9114-886AA0C3B69FQ27660385-F4A7C59E-1EF2-4838-A027-6EEE8743A9D3Q27675049-4810796A-8B26-4F96-AB96-5F965BD3F618Q27698513-458B4A81-8188-4DF9-B73B-92B718B1686AQ28067636-00641E40-B1FC-4FAE-B30D-FFE126F780D9Q28070292-8AB00DE4-AF57-40FA-9E35-1DF4434E72E0Q28250733-3C4FCBF4-B127-4BB3-A1E4-B8D65906BBDEQ28396643-8596EDC0-D8E6-4191-8787-D75807BD75EEQ28469170-B1EB5369-2754-4F58-B7D0-6D2F3EB4E128Q28475117-5CF8EFC0-ADFF-4E09-953E-122BAADDFEC9Q28504995-33D60785-76CF-4D18-9F7A-0EE6A060D151Q28543640-A5C75BD0-AE76-43AA-8023-BF6BFA26E97FQ28546849-8A61F435-59ED-48C0-869D-CF2736E2FDE4Q28551159-3EAE4A9D-E19C-4FBC-B3F7-A94BEB2CFCCAQ30008895-D9F841BC-C5A7-4B6C-B5B7-59B481DF63D0Q30008899-3B24AC15-F451-47F0-ACED-FF0E496B2CE9Q30008916-6DB4C5AF-C09D-4E1B-9BAE-6D1CA2E72BFBQ30008917-D0B014B7-4CAC-4179-B1BE-2D2D897933E0Q30009269-6937C2A6-B895-4CCE-889E-5A3B49E5900FQ30009328-2666230B-1FB0-4EC3-8F5F-E29439515CD8Q30009343-D6EC47D2-5BD9-4B69-BE85-F8B9A0ACDEB9Q30009530-E6C086BC-7AD4-45F9-8404-334F06C4F412Q30009582-D05DE23E-90D8-4C80-9164-119097CA9983Q30009592-D390FC9C-60EE-4732-8559-BAFE72848689Q30009855-EB442181-4767-4596-9869-E10873C61F14Q30009947-DE429A83-A8FF-4DEF-A62F-6740CC8D22D8Q30010218-0C037D60-0C91-4B07-B5FB-B53200D4CC03Q30156102-EA9A6F09-BD74-4733-A583-69D810D5E11A
P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Regulation of the c-Abl and Bcr-Abl tyrosine kinases.
@ast
Regulation of the c-Abl and Bcr-Abl tyrosine kinases.
@en
type
label
Regulation of the c-Abl and Bcr-Abl tyrosine kinases.
@ast
Regulation of the c-Abl and Bcr-Abl tyrosine kinases.
@en
prefLabel
Regulation of the c-Abl and Bcr-Abl tyrosine kinases.
@ast
Regulation of the c-Abl and Bcr-Abl tyrosine kinases.
@en
P356
P1476
Regulation of the c-Abl and Bcr-Abl tyrosine kinases.
@en
P2888
P356
10.1038/NRM1280
P577
2004-01-01T00:00:00Z