SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation - Wikidata - awgldk - TriplyDB

SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation

SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation

http://www.wikidata.org/entity/Q35621518

about

Cullin-RING ligases in regulation of autophagy Fbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human Tumorigenesis A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor FBW7-mediated ubiquitination and degradation of KLF5 Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis.Aberrant regulation of FBW7 in cancer.E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration Negative regulation of DAB2IP by Akt and SCFFbw7 pathways Ubiquitination by SAG regulates macrophage survival/death and immune response during infection.Inactivation of SAG E3 ubiquitin ligase blocks embryonic stem cell differentiation and sensitizes leukemia cells to retinoid acid.Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy Inactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalization Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis Tumor suppressor functions of FBW7 in cancer development and progression.Feedback activation of neurofibromin terminates growth factor-induced Ras activation.Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer.Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis.Suppression of tumor angiogenesis by targeting the protein neddylation pathway.RNF7 knockdown inhibits prostate cancer tumorigenesis by inactivation of ERK1/2 pathway.Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase.Cullin-RING Ligases as attractive anti-cancer targets.Cell regulation by phosphotyrosine-targeted ubiquitin ligases.Recent advances in SCF ubiquitin ligase complex: Clinical implications Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability.The FBW7-KLF2 axis regulates endothelial functions.ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities.

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P2860

SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation

http://www.wikidata.org/entity/Q35621518

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

SAG/RBX2/ROC2 E3 ubiquitin lig ...... targeting NF1 for degradation

@ast

SAG/RBX2/ROC2 E3 ubiquitin lig ...... targeting NF1 for degradation

@en

type

label

SAG/RBX2/ROC2 E3 ubiquitin lig ...... targeting NF1 for degradation

@ast

SAG/RBX2/ROC2 E3 ubiquitin lig ...... targeting NF1 for degradation

@en

prefLabel

SAG/RBX2/ROC2 E3 ubiquitin lig ...... targeting NF1 for degradation

@ast

SAG/RBX2/ROC2 E3 ubiquitin lig ...... targeting NF1 for degradation

@en

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J.DEVCEL.2011.09.014

P1433

Developmental Cell

P1476

SAG/RBX2/ROC2 E3 ubiquitin lig ...... targeting NF1 for degradation

@en

P2093

Lijun Jia

http://www.w3.org/2001/XMLSchema#string

Margaret Liu

http://www.w3.org/2001/XMLSchema#string

Mingjia Tan

http://www.w3.org/2001/XMLSchema#string

Sun-Jung Kim

http://www.w3.org/2001/XMLSchema#string

Thomas L Saunders

http://www.w3.org/2001/XMLSchema#string

Yi Sun

http://www.w3.org/2001/XMLSchema#string

Yongchao Zhao

http://www.w3.org/2001/XMLSchema#string

Yuan Zhu

http://www.w3.org/2001/XMLSchema#string

P2860

SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Systematic analysis and nomenclature of mammalian F-box proteins

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

Somatic mutations affect key pathways in lung adenocarcinoma

An integrated genomic analysis of human glioblastoma multiforme

Tumor microenvironment and neurofibromatosis type I: connecting the GAPs

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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1062-1076

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10.1016/J.DEVCEL.2011.09.014

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6

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21

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2011-11-23T00:00:00Z

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51835753

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22118770

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3241850

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