about
Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesInborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypesPopulation genetics and human immunity: the interferon paradigmPopulation genetic tools for dissecting innate immunity in humansGenetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactionsStructural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.Understanding rare and common diseases in the context of human evolutionInterferons and viruses: an evolutionary arms race of molecular interactionsDissecting structural and nucleotide genome-wide variation in inbred Iberian pigs.Innate immune activity conditions the effect of regulatory variants upon monocyte gene expressionIFN-λ exerts opposing effects on T cell responses depending on the chronicity of the virus infection.The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs.Selection on a variant associated with improved viral clearance drives local, adaptive pseudogenization of interferon lambda 4 (IFNL4)IFN-λ4: the paradoxical new member of the interferon lambda family.Molecular evolution of the porcine type I interferon family: subtype-specific expression and antiviral activity.Differential activity of type I interferon subtypes for dendritic cell differentiationIFN-ε is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines.An evolutionary analysis of antigen processing and presentation across different timescales reveals pervasive selection.Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.Genomic diversity and admixture differs for Stone-Age Scandinavian foragers and farmers.Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector MechanismsThe evolutionary landscape of cytosolic microbial sensors in humans.Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance.The human gene damage index as a gene-level approach to prioritizing exome variants.Engineered Mammalian RNAi Can Elicit Antiviral Protection that Negates the Requirement for the Interferon Response.Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity GenesA genome-wide perspective of human diversity and its implications in infectious disease.Tissue-specific interferon alpha subtype response to SIV infection in brain, spleen, and lung.Evidence for adaptation of porcine Toll-like receptors.Selective Landscapes in newt Immune Genes Inferred from Patterns of Nucleotide Variation.High cord blood CCL22/CXCL10 chemokine ratios precede allergic sensitization in early childhood.Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases.Interferon signatures in immune disorders and disease.IFNA2: The prototypic human alpha interferon.The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections.Evolution of Cytokine Receptor Signaling.Living in an adaptive world: Genomic dissection of the genus Homo and its immune response.Interleukin-37 gene variants segregated anciently coexist during hominid evolution.High-throughput quantitative real-time RT-PCR assay for determining expression profiles of types I and III interferon subtypes.An in vitro diagnostic certified point of care single nucleotide test for IL28B polymorphisms.
P2860
Q21131160-5221DF41-AD34-43C6-B64E-2FDBA3B5D66EQ26825342-5B6010B1-59E4-4383-B481-779276C91A2BQ26830286-A19CD545-EABC-4DAA-AC3A-62312C3AB77BQ27001032-FEF7659F-ED40-4688-A7CF-2F00185098B6Q27014831-C5CA5FB8-A90E-4D6B-AD90-69706071D906Q27687338-AF485A80-0E68-4983-824F-047D1007F05BQ28067740-FB035117-9EFB-439E-9C4E-CEFB04EE58F5Q28083788-6F1F511E-A04E-41BA-9DD6-55E298537F99Q30537797-C5E7998C-2111-410A-9D14-35EDC9DA40F2Q33783132-D5D82293-B78A-4F46-9258-539F783CE703Q34147632-1EACB56A-76A5-4C0A-A8D1-F4FF7F5119CDQ34281428-A33F8825-7D2C-4D9A-B136-88CD76653941Q34350873-E3BD1F64-464E-441C-88B3-6264D743EC6CQ34439917-4CCA718C-23F8-4F68-B020-45153A25DD68Q34458694-9FD55047-5BF7-4127-97CF-3917A12C48ECQ34615006-5412073C-BE07-459B-BAD2-570487D53EE4Q34949247-CE2C751A-3C76-4CA5-BA23-E8B494E3A7AFQ35133190-A5586C89-AD72-4508-A9BD-13B7F64D9DBDQ35147055-DE2BF741-6905-4EAF-AB2A-E24E92A45556Q35156734-5AAAF3B4-7B73-490E-88A0-B10173861794Q35830651-22325922-FB29-4488-B032-D08070AFCA47Q36096120-542FA11C-A148-4ED7-A6A6-3AA56D86EAF5Q36190873-0541AC67-65B6-4D6F-88D7-52F7A60EDCBBQ36268400-DFE8AD50-E944-4BB1-980E-450287BE085CQ36304385-3953ED7A-2336-4CF8-B2ED-1FB3AA54B104Q36473385-9B87198D-31DC-45E3-9ABA-21A5C4AB6F1CQ36488254-8D51ABFF-3563-454D-92C8-85A548166C6BQ36515464-37264EFD-8BED-47F5-B24E-A307D99C151DQ36594809-8ED802F7-AC24-48D4-A3D9-A1068D049990Q37547317-B252599A-03B4-4C78-95B2-200CBF188319Q37702526-18C28B7A-902D-4F64-9E0A-8BA83F49E50AQ37737549-1B3E45F4-4ABF-45E4-8FFE-BD864328CCE9Q38001532-38555F12-8AF8-4569-AF99-8BC43428157FQ38486383-82DF3AB7-FA04-48CC-9A95-ADD33580FF46Q38514365-6A1A86D1-E9CB-4AC5-8C7A-EB0FF55D048EQ38869059-2F6466A9-CDF1-418C-8717-D529ACC6FD52Q38870254-B420FE27-1300-4276-A5FD-21ABEB3022AEQ39642337-F142AC5D-009F-45CC-9DDF-357D8C7C5BBEQ39743537-3E4107BC-6885-4AA9-9F80-4EB583DFAFC5Q40055793-099D49F4-B91B-4D60-A5E6-1570E3745847
P2860
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Evolutionary genetic dissection of human interferons.
@ast
Evolutionary genetic dissection of human interferons.
@en
type
label
Evolutionary genetic dissection of human interferons.
@ast
Evolutionary genetic dissection of human interferons.
@en
prefLabel
Evolutionary genetic dissection of human interferons.
@ast
Evolutionary genetic dissection of human interferons.
@en
P2093
P2860
P50
P356
P1476
Evolutionary genetic dissection of human interferons.
@en
P2093
Guillaume Laval
Jérémy Manry
Simona Fornarino
Yuval Itan
P2860
P304
P356
10.1084/JEM.20111680
P407
P50
P577
2011-12-12T00:00:00Z