about
Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?Gene therapy approaches to regenerating the musculoskeletal systemAllelic variants of IL1R1 gene associate with severe hand osteoarthritis.Use of stem cells in the biological repair of articular cartilage.Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover.Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model.Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis.Gene transfer to human joints: progress toward a gene therapy of arthritisTemporal expression and tissue distribution of interleukin-1β in two strains of guinea pigs with varying propensity for spontaneous knee osteoarthritis.Key Pathways to Prevent Posttraumatic Arthritis for Future Molecule-Based Therapy.Clinical potential and challenges of using genetically modified cells for articular cartilage repair.Preclinical studies on mesenchymal stem cell-based therapy for growth plate cartilage injury repairMesenchymal stem cells and articular cartilage repair: clinical studies and future direction.Intra-articular delivery of anti-Hif-2α siRNA by chondrocyte-homing nanoparticles to prevent cartilage degeneration in arthritic mice.Effective reduction of the interleukin-1β transcript in osteoarthritis-prone guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences gene expression of mediators implicated in disease pathogenesisInhibition of interleukin 1-induced matrix metalloproteinase 13 expression in human chondrocytes by interferon gamma.Major biological obstacles for persistent cell-based regeneration of articular cartilage.Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment.Persistence, localization, and external control of transgene expression after single injection of adeno-associated virus into injured joints.Adeno-associated viral vectors show serotype specific transduction of equine joint tissue explants and cultured monolayersConcepts in gene therapy for cartilage repair.Gene therapy of the rheumatic diseases: 1998 to 2008.Treatment of osteoarthritis using a helper-dependent adenoviral vector retargeted to chondrocytesTreating human meniscal fibrochondrocytes with hIGF-1 gene by liposomeEnhanced meniscal repair by overexpression of hIGF-1 in a full-thickness model.Proteomics of osteoarthritic chondrocytes and cartilage.Mesenchymal stem cell-based treatment for cartilage defects in osteoarthritis.Advances and challenges in gene-based approaches for osteoarthritis.Drug delivery systems for intra-articular treatment of osteoarthritis.Gene Therapy for Cartilage Repair.Gene delivery of osteoinductive signals to a human fetal osteoblast cell line induces cell death in a dose-dependent manner.Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explants.Stem cells and gene therapy for cartilage repair.Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis.Ex vivo serotype-specific transduction of equine joint tissue by self-complementary adeno-associated viral vectors.Inhibition of vascular endothelial growth factor with shRNA in chondrocytes ameliorates osteoarthritis.In vitro suppression of the MMP-3 gene in normal and cytokine-treated human chondrosarcoma using small interfering RNA.Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits.Production of recombinant AAV vectors encoding insulin-like growth factor I is enhanced by interaction among AAV rep regulatory sequences.Intraarticular application of autologous conditioned serum (ACS) reduces bone tunnel widening after ACL reconstructive surgery in a randomized controlled trial.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Osteoarthritis gene therapy.
@ast
Osteoarthritis gene therapy.
@en
type
label
Osteoarthritis gene therapy.
@ast
Osteoarthritis gene therapy.
@en
prefLabel
Osteoarthritis gene therapy.
@ast
Osteoarthritis gene therapy.
@en
P2093
P2860
P356
P1433
P1476
Osteoarthritis gene therapy.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.GT.3302196
P577
2004-02-01T00:00:00Z
P5875
P6179
1038726748