Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. - Wikidata - awgldk - TriplyDB

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

http://www.wikidata.org/entity/Q35636877

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Cancer genome landscapes The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers Molecular and Cellular Mechanisms of Myelodysplastic Syndrome: Implications on Targeted Therapy Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis Defects in spliceosomal machinery: a new pathway of leukaemogenesis From human genome to cancer genome: the first decade Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?Connections between TET proteins and aberrant DNA modification in cancer Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease Myeloid malignancies: mutations, models and management Emerging patterns of somatic mutations in cancer Cancer-relevant Splicing Factor CAPERα Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex U2AF1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.SF3B1 mutations in chronic lymphocytic leukemia.Clinical implications of U2AF1 mutation in patients with myelodysplastic syndrome and its stability during disease progression.Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations Emerging concepts of epigenetic dysregulation in hematological malignancies Defective control of pre-messenger RNA splicing in human disease The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML How do messenger RNA splicing alterations drive myelodysplasia?The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.Genomic landscape of CD34+ hematopoietic cells in myelodysplastic syndrome and gene mutation profiles as prognostic markers.The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH Targeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms.Aberrant RNA splicing and mutations in spliceosome complex in acute myeloid leukemia.What are we learning from the cancer genome?Cancer genomics and pathology: all together now.Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria.Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation Kinetic competition during the transcription cycle results in stochastic RNA processing.An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth The spliceosome is a therapeutic vulnerability in MYC-driven cancer.Functional study of one nucleotide mutation in pri-miR-125a coding region which related to recurrent pregnancy loss.Pathogenesis of myelodysplastic syndromes: an overview of molecular and non-molecular aspects of the disease.Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing

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Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

http://www.wikidata.org/entity/Q35636877

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2011年论文

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2011年论文

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name

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

@ast

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

@en

type

label

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

@ast

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

@en

prefLabel

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

@ast

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

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Nature Genetics

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Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

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Cara L Lunn

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Christopher C Harris

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Daniel C Koboldt

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Daniel C Link

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David E Larson

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David J Dooling

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Dong Shen

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Elaine R Mardis

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Heather Schmidt

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Jack Baty

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A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer

Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Significance analysis of microarrays applied to the ionizing radiation response

Recurring mutations found by sequencing an acute myeloid leukemia genome

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

Fast and accurate short read alignment with Burrows-Wheeler transform

DAVID: Database for Annotation, Visualization, and Integrated Discovery

DNMT3A Mutations in Acute Myeloid Leukemia

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10.1038/NG.1031

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1

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44

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Kilannin Krysiak

Timothy A. Graubert

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2011-12-11T00:00:00Z

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51868516

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22158538

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3247063

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