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Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.

http://www.wikidata.org/entity/Q35637501

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A transposon and transposase system for human application The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral pathogenesis and its relevance to retroviral vector-mediated gene delivery iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System Genome-editing Technologies for Gene and Cell Therapy Cardiovascular gene therapy for myocardial infarction Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration Excision of HIV-1 proviral DNA by recombinant cell permeable tre-recombinase Barriers to inhaled gene therapy of obstructive lung diseases: A review Treatments for choroidal and retinal neovascularization: a focus on oligonucleotide therapy and delivery for the regulation of gene function.Group II intron-based gene targeting reactions in eukaryotes.Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator.Factors influencing the DNA nuclease activity of iron, cobalt, nickel, and copper chelates.δ-Catenin, a Wnt/β-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.Translating Sleeping Beauty transposition into cellular therapies: victories and challenges.MAR-mediated integration of plasmid vectors for in vivo gene transfer and regulation In vivo biosafety model to assess the risk of adverse events from retroviral and lentiviral vectors.LDLR-Gene therapy for familial hypercholesterolaemia: problems, progress, and perspectives Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.Genetic barcode sequencing for screening altered population dynamics of hematopoietic stem cells transduced with lentivirus Pois(s)on--it's a question of dose...Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene.Improved transduction of human sheep repopulating cells by retrovirus vectors pseudotyped with feline leukemia virus type C or RD114 envelopes.Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT.Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells.Retroviral vectors: new applications for an old tool.Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression.Targeted cleavage of HIV RRE RNA by Rev-coupled transition metal chelates.Retargeting transposon insertions by the adeno-associated virus Rep protein.Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy.Genetic modification of hematopoietic stem cells with nonviral systems: past progress and future prospects.Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains.Gene therapy for pituitary tumors.Gene therapy for treatment of inherited haematological disorders.HOXB4 and retroviral vectors: adding fuel to the fire.Construction and characterization of an in-vivo linear covalently closed DNA vector production system.Gene therapy for Wiskott-Aldrich Syndrome-Long-term reconstitution and clinical benefits, but increased risk for leukemogenesis.Whole-genome mutational burden analysis of three pluripotency induction methods.

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Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.

http://www.wikidata.org/entity/Q35637501

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.

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Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.

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type

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Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.

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Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.

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prefLabel

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.

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Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.

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J.YMTHE.2003.10.013

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Molecular Therapy

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Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.

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Christopher Baum

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David A Williams

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Floor Weerkamp

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Frank J T Staal

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Gerard Wagemaker

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Manfred Schmidt

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Stefan Karlsson

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Zhixiong Li

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scholarly article

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10.1016/J.YMTHE.2003.10.013

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1

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9

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Christof von Kalle

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2004-01-01T00:00:00Z

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8903893

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