Structural basis for inhibition of translation by the tumor suppressor Pdcd4. - Wikidata - awgldk - TriplyDB

Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

http://www.wikidata.org/entity/Q35641705

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Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65 RNA helicases at work: binding and rearranging PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains Structures of the Shigella flexneri Type 3 Secretion System Protein MxiC Reveal Conformational Variability Amongst Homologues Structural basis for translational inhibition by the tumour suppressor Pdcd4 Crystal structure of the eIF4A-PDCD4 complex Structure of the Tandem MA-3 Region of Pdcd4 Protein and Characterization of Its Interactions with eIF4A and eIF4G High-resolution structure of Bombyx mori lipoprotein 7: crystallographic determination of the identity of the protein and its potential role in detoxification Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4.Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability.Signal transduction molecules as targets for cancer prevention.Have tumor suppressor PDCD4 and its counteragent oncogenic miR-21 gone rogue?Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma.Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1.The unique evolution of the programmed cell death 4 protein in plants.Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo.Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4.Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600 Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2.Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer.Pdcd4 restrains the self-renewal and white-to-beige transdifferentiation of adipose-derived stem cells.Programmed cell death 4 (PDCD4) suppresses metastastic potential of human hepatocellular carcinoma cells.The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation.The biological and therapeutic relevance of mRNA translation in cancer.Inhibitors of translation initiation as cancer therapeutics.Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated.Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway.A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation.Programmed cell death 4 mechanism of action: the model to be updated?Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation.Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA.Disruption of the Pdcd4 tumor suppressor gene in chicken DT40 cells reveals its role in the DNA-damage response.Downregulation of PDCD4 by miR-21 suppresses tumor transformation and proliferation in a nude mouse renal cancer model.Housekeeping genes in prostate tumorigenesis.An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4.Association of Tumor Suppressor Protein Pdcd4 With Ribosomes Is Mediated by Protein-Protein and Protein-RNA Interactions Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46.Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.

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P2860

Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

http://www.wikidata.org/entity/Q35641705

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

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Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

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Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

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Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

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Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

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Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

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Molecular and Cellular Biology

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Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

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Alexander Wlodawer

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Alyson R Baker

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Arti N Santhanam

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Nancy H Colburn

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Nicole LaRonde-LeBlanc

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P2860

Akt phosphorylates and regulates Pdcd4 tumor suppressor protein

Structural basis for the enhancement of eIF4A helicase activity by eIF4G.

Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion

Electrostatics of nanosystems: application to microtubules and the ribosome

A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A

Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes

A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery

Crystal structure of the human nuclear cap binding complex

SOLVE and RESOLVE: automated structure solution and density modification

Coot: model-building tools for molecular graphics

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10.1128/MCB.00867-06

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1

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27

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1800662

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