Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila
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Proliferation control in neural stem and progenitor cellsIt takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brainThe transcription factor Nerfin-1 prevents reversion of neurons into neural stem cellsThe bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brainDrosophila neuroblasts as a new model for the study of stem cell self-renewal and tumour formation.Translational control in germline stem cell development.Conserved regulators of nucleolar size revealed by global phenotypic analyses.The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch.Downregulation of the Host Gene jigr1 by miR-92 Is Essential for Neuroblast Self-Renewal in Drosophila.Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells.Analysis of cell identity, morphology, apoptosis and mitotic activity in a primary neural cell culture system in Drosophila.klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division.Cancer stem cells and cell size: A causal link?Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster.Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor EarmuffFACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal.Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activityRoles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway.The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth.Balancing self-renewal and differentiation by asymmetric division: insights from brain tumor suppressors in Drosophila neural stem cells.Drosophila neural stem cells in brain development and tumor formation.Understanding how differentiation is maintained: lessons from the Drosophila brain.Drosophila mbm is a nucleolar myc and casein kinase 2 target required for ribosome biogenesis and cell growth of central brain neuroblasts.Cortical aPKC kinase activity distinguishes neural stem cells from progenitor cells by ensuring asymmetric segregation of Numb.Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca(2+) Homeostasis in Neural Stem Cell Development.The Ets protein Pointed prevents both premature differentiation and dedifferentiation of Drosophila intermediate neural progenitors.Aging Neural Progenitors Lose Competence to Respond to Mitogenic Notch Signaling.Genes implicated in stem cell identity and temporal programme are directly targeted by Notch in neuroblast tumoursNotch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme.L-serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E-BP1 and subsequent repression of translation initiation in the developing central nervous system.bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression.Imp and Syp RNA-binding proteins govern decommissioning of Drosophila neural stem cells.The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda.Variant cell cycles regulated by Notch signaling control cell size and ensure a functional blood-brain barrier.Myc function in Drosophila.Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loopMyc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity inThe retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking
P2860
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P2860
Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Regulation of cell growth by N ...... rming stem cells in Drosophila
@ast
Regulation of cell growth by N ...... rming stem cells in Drosophila
@en
type
label
Regulation of cell growth by N ...... rming stem cells in Drosophila
@ast
Regulation of cell growth by N ...... rming stem cells in Drosophila
@en
prefLabel
Regulation of cell growth by N ...... rming stem cells in Drosophila
@ast
Regulation of cell growth by N ...... rming stem cells in Drosophila
@en
P2860
P356
P1433
P1476
Regulation of cell growth by N ...... rming stem cells in Drosophila
@en
P2093
P2860
P304
P356
10.1101/GAD.171959.111
P577
2011-12-01T00:00:00Z