Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin
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Causes of evolutionary rate variation among protein sitesFunctional Sites Induce Long-Range Evolutionary Constraints in EnzymesDoes Influenza Pandemic Preparedness and Mitigation require Gain-Of-Function Research?Viral factors in influenza pandemic risk assessment.The utility of protein structure as a predictor of site-wise dN/dS varies widely among HIV-1 proteins.Time dependence of evolutionary metrics during the 2009 pandemic influenza virus outbreak.Dissecting the roles of local packing density and longer-range effects in protein sequence evolutionDetermination of antigenicity-altering patches on the major surface protein of human influenza A/H3N2 virusesComputational and Functional Analysis of the Virus-Receptor Interface Reveals Host Range Trade-Offs in New World Arenaviruses.A CRISPR/Cas9 and Cre/Lox system-based express vaccine development strategy against re-emerging Pseudorabies virus.Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 seasonSequence amplification via cell passaging creates spurious signals of positive adaptation in influenza virus H3N2 hemagglutininCalculating site-specific evolutionary rates at the amino-acid or codon level yields similar rate estimates.A Comparison of One-Rate and Two-Rate Inference Frameworks for Site-Specific dN/dS Estimation.Molecular Evolutionary Constraints that Determine the Avirulence State of Clostridium botulinum C2 Toxin.Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins.Predictive Modeling of Influenza Shows the Promise of Applied Evolutionary Biology.phylotree.js - a JavaScript library for application development and interactive data visualization in phylogeneticsThe influenza virus hemagglutinin head evolves faster than the stalk domain
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P2860
Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin
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2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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name
Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin
@ast
Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin
@en
type
label
Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin
@ast
Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin
@en
prefLabel
Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin
@ast
Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin
@en
P2860
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Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin
@en
P2860
P304
P356
10.1371/JOURNAL.PPAT.1004940
P577
2015-05-28T00:00:00Z