Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1. - Wikidata - awgldk - TriplyDB

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.

http://www.wikidata.org/entity/Q35645174

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The MHC locus and genetic susceptibility to autoimmune and infectious diseases.A Genome-Wide SNP Linkage Analysis Suggests a Susceptibility Locus on 6p21 for Ankylosing Spondylitis and Inflammatory Back Pain Trait.Comparison of HLA allelic imputation programs.Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2 An HLA-C amino-acid variant in addition to HLA-B*27 confers risk for ankylosing spondylitis in the Korean population.Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis.Review: Enthesitis: New Insights Into Pathogenesis, Diagnostic Modalities, and Treatment.ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations.The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion.Epigenetic and gene expression analysis of ankylosing spondylitis-associated loci implicate immune cells and the gut in the disease pathogenesis.Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank.10 Years of GWAS Discovery: Biology, Function, and Translation.Pathogenesis of ankylosing spondylitis - recent advances and future directions.New insights toward the pathogenesis of ankylosing spondylitis; genetic variations and epigenetic modifications.Functional Genomics and Its Bench-to-Bedside Translation Pertaining to the Identified Susceptibility Alleles and Loci in Ankylosing Spondylitis.New insights into the understanding of MHC associations with immune-mediated disorders.Pain in ankylosing spondylitis: a neuro-immune collaboration.The Ankylosing Spondylitis-associated HLA-B*2705 presents a B*0702-restricted EBV epitope and sustains the clonal amplification of cytotoxic T cells in patients.The interplay between HLA-B27 and ERAP1/ERAP2 aminopeptidases: from anti-viral protection to spondyloarthritis.The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases.Cross-phenotype association mapping of the MHC identifies genetic variants that differentiate psoriatic arthritis from psoriasis.Ethnicity and disease severity in ankylosing spondylitis a cross-sectional analysis of three ethnic groups.Immunogenetic Factors in Early Immune Control of Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Evaluation of HLA Class I Amino Acid Variants in Two African Populations Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality.Exploiting non-canonical translation to identify new targets for T cell-based cancer immunotherapy.Progress of genome-wide association studies of ankylosing spondylitis.Crystal structure of a polypeptide's C-terminus in complex with the regulatory domain of ER aminopeptidase 1.The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis.Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism.'MHC-I-opathy'-unified concept for spondyloarthritis and Behçet disease.ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population.Novel HLA class I associations with HIV-1 control in a unique genetically admixed population.Non-classical human leucocyte antigens in ankylosing spondylitis: possible association with HLA-E and HLA-F.Recent advances in ankylosing spondylitis: understanding the disease and management How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis Distinct mechanisms survey the structural integrity of HLA-B*27:05 intracellularly and at the surface Progress in our understanding of the pathogenesis of ankylosing spondylitis

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Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.

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2015 nî lūn-bûn

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Major histocompatibility compl ...... further epistasis with ERAP1.

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Nature Communications

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Major histocompatibility compl ...... further epistasis with ERAP1.

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Adrian Cortes

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Benedicte A Lie

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Bryan Paul Wordsworth

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C Lopez-Larrea

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Claire Farrah

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Consuelo Romero-Sánchez

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Dirk Elewaut

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Fernando M Pimentel-Santos

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Francisco J Blanco

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Gilles Chiocchia

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Structural Basis for T Cell Alloreactivity among Three HLA-B14 and HLA-B27 Antigens

Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

Imputing amino acid polymorphisms in human leukocyte antigens.

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10.1038/NCOMMS8146

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6

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Jaakko Tuomilehto

Dafna D. Gladman

Johannes C Nossent

Rubén Burgos-Vargas

Irene van der Horst-Bruinsma

Robert D. Inman

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2015-05-21T00:00:00Z

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25994336

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4443427

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