Artemisinin derivatives: toxic for laboratory animals, safe for humans?
about
Identification of an antimalarial synthetic trioxolane drug development candidateDeconvoluting heme biosynthesis to target blood-stage malaria parasitesArtesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cellsDihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cellsA safety assessment of the antimalarial herb Artemisia annua during pregnancy in Wistar rats.Intravenous artesunate for the treatment of severe malaria.Malaria: an update on current chemotherapy.Discovery, mechanisms of action and combination therapy of artemisininSubchronic toxicological study of two artemisinin derivatives in dogsMeningeal inflammation increases artemether concentrations in cerebrospinal fluid in Papua New Guinean children treated with intramuscular artemether.Artemisinins.Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drugPrevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New GuineaSemi-mechanistic pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of artemisinin.Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria.Artesunate-amodiaquine for the treatment of uncomplicated malaria.In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivativesOtotoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial.Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisininArtemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signalingRole of oxidative stress in stem, cancer, and cancer stem cells.Toxicity of the antimalarial artemisinin and its dervatives.The pharmacokinetic evaluation of artemisinin drugs for the treatment of malaria in paediatric populations.Anticancer Effect of AntiMalarial Artemisinin Compounds.Artemisinin rewires the protein interaction network in cancer cells: network analysis, pathway identification, and target prediction.Synthesis and cytotoxicity of novel 10-substituted dihydroartemisinin derivatives containing N-arylphenyl-ethenesulfonamide groups.In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents.Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins.Artemether-lumefantrine and liver enzyme abnormalities in non-severe Plasmodium falciparum malaria in returned travellers: a retrospective comparative study with quinine-doxycycline in a Portuguese centre.Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines.Connexin-43 enhances tumor suppressing activity of artesunate via gap junction-dependent as well as independent pathways in human breast cancer cells.Dihydroartemisinin targets VEGFR2 via the NF-κB pathway in endothelial cells to inhibit angiogenesis.Dihydroartemisinin inhibits vascular endothelial growth factor-induced endothelial cell migration by a p38 mitogen-activated protein kinase-independent pathway.Stability and antiviral activity against human cytomegalovirus of artemisinin derivatives.Artemisinin derivatives with long elimination half-life.Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway.Dihydroartemisinin, an Anti-Malaria Drug, Suppresses Estrogen Deficiency-Induced Osteoporosis, Osteoclast Formation, and RANKL-Induced Signaling Pathways.Effects of artemisinin in broiler chickens following chronic oral intake.Prospective open uncontrolled phase I study to define a well-tolerated dose of oral artesunate as add-on therapy in patients with metastatic breast cancer (ARTIC M33/2).Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin.
P2860
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P2860
Artemisinin derivatives: toxic for laboratory animals, safe for humans?
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Artemisinin derivatives: toxic for laboratory animals, safe for humans?
@ast
Artemisinin derivatives: toxic for laboratory animals, safe for humans?
@en
type
label
Artemisinin derivatives: toxic for laboratory animals, safe for humans?
@ast
Artemisinin derivatives: toxic for laboratory animals, safe for humans?
@en
prefLabel
Artemisinin derivatives: toxic for laboratory animals, safe for humans?
@ast
Artemisinin derivatives: toxic for laboratory animals, safe for humans?
@en
P1433
P1476
Artemisinin derivatives: toxic for laboratory animals, safe for humans?
@en
P2093
Eve Irene Lepist
Toufigh Gordi
P304
P356
10.1016/J.TOXLET.2003.12.009
P577
2004-03-01T00:00:00Z