Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair. - Wikidata - awgldk - TriplyDB

Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair.

Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair.

http://www.wikidata.org/entity/Q35646746

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair The current state of eukaryotic DNA base damage and repair Dynamic DNA methylation in the brain: a new epigenetic mark for experience-dependent plasticity Active DNA demethylation of the vertebrate genomes by DNA methyltransferases: deaminase, dehydroxymethylase or demethylase?Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability The mutational spectrum of non-CpG DNA varies with CpG content A TDG/CBP/RARα ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes Base excision repair of tandem modifications in a methylated CpG dinucleotide.Active demethylation in mouse zygotes involves cytosine deamination and base excision repair SUMO-1 regulates the conformational dynamics of thymine-DNA Glycosylase regulatory domain and competes with its DNA binding activity.Using a medium-throughput comet assay to evaluate the global DNA methylation status of single cells.Active DNA demethylation: many roads lead to Rome.DNA methyltransferases, DNA damage repair, and cancer Recent advances in the structural mechanisms of DNA glycosylases 5-Hydroxymethylcytosine: a stable or transient DNA modification?CpG methylation in neurons: message, memory, or mask?Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption.Active DNA demethylation mediated by DNA glycosylases.Regulation and function of DNA methylation in plants and animals.A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation.DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations.Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53 Base excision repair, aging and health span.Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells.Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a DNA demethylation by TDG.5-hydroxymethylcytosine: a potential therapeutic target in cancer.Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA.DNA methylation: dynamic and stable regulation of memory.Driver mutations of cancer epigenomes.BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management.Epigenetic Mechanisms as an Interface Between the Environment and Genome.Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases.A sensitive, homogeneous fluorescence assay for detection of thymine DNA glycosylase activity based on exonuclease-mediated amplification.

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P2860

Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair.

http://www.wikidata.org/entity/Q35646746

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2006 nî lūn-bûn

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Association of Dnmt3a and thym ...... ion with base-excision repair.

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Association of Dnmt3a and thym ...... ion with base-excision repair.

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Association of Dnmt3a and thym ...... ion with base-excision repair.

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Association of Dnmt3a and thym ...... ion with base-excision repair.

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Association of Dnmt3a and thym ...... ion with base-excision repair.

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Nucleic Acids Research

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Association of Dnmt3a and thym ...... tion with base-excision repair

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Guo-Liang Xu

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Ping-Zhu Zhou

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Xiu-Dan Zheng

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Ya-Qiang Li

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P2860

DNA methylation patterns and epigenetic memory

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover

Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase

The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds

The fundamental role of epigenetic events in cancer

CpG-rich islands and the function of DNA methylation

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DNA methylation

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1802599

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