A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain.
about
Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouseThe pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease statesCellular interplay between neurons and glia: toward a comprehensive mechanism for excitotoxic neuronal loss in neurodegenerationMolecular mechanisms of acrolein-mediated myelin destruction in CNS trauma and diseaseAntisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis.SNJ-1945, a calpain inhibitor, protects SH-SY5Y cells against MPP(+) and rotenone.Reactive microgliosis: extracellular micro-calpain and microglia-mediated dopaminergic neurotoxicity.A novel haplotype-sharing approach for genome-wide case-control association studies implicates the calpastatin gene in Parkinson's diseaseCross-talk between IGF-1 and estrogen receptors attenuates intracellular changes in ventral spinal cord 4.1 motoneuron cells because of interferon-gamma exposure.Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis.Calpain inhibition attenuates intracellular changes in muscle cells in response to extracellular inflammatory stimulation.Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitorsInhibition of myelin-cleaving poteolytic activities by interferon-beta in rat astrocyte cultures. Comparative analysis between gelatinases and calpain-IIDecreased activity of the 20S proteasome in the brain white matter and gray matter of patients with multiple sclerosis.Schwann cell spectrins modulate peripheral nerve myelination.Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis.Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis.Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neuronsQuantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosisInhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice.Membrane Repair: Mechanisms and Pathophysiology.Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patientsProteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry.Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis.SNPs in CAST are associated with Parkinson disease: a confirmation study.Mechanisms of neuronal damage in multiple sclerosis and its animal models: role of calcium pumps and exchangers.Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis.The role of chromogranin B in an animal model of multiple sclerosis.Calpain-mediated signaling mechanisms in neuronal injury and neurodegenerationInhibition of calpain attenuates encephalitogenicity of MBP-specific T cells.Sexual dimorphism in the white matter of rodents.Critical role of calpain in spinal cord degeneration in Parkinson's diseaseThe Involvement of Calpain in CD4(+) T Helper Cell Bias in Multple Sclerosis.The calpain system and cancer.Calpain system and its involvement in myocardial ischemia and reperfusion injury.Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis.Calpeptin attenuated apoptosis and intracellular inflammatory changes in muscle cellsCleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2.Administration of low dose estrogen attenuates gliosis and protects neurons in acute spinal cord injury in rats.
P2860
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P2860
A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
A putative mechanism of demyel ...... a proteolytic enzyme, calpain.
@ast
A putative mechanism of demyel ...... a proteolytic enzyme, calpain.
@en
type
label
A putative mechanism of demyel ...... a proteolytic enzyme, calpain.
@ast
A putative mechanism of demyel ...... a proteolytic enzyme, calpain.
@en
prefLabel
A putative mechanism of demyel ...... a proteolytic enzyme, calpain.
@ast
A putative mechanism of demyel ...... a proteolytic enzyme, calpain.
@en
P2093
P2860
P356
P1476
A putative mechanism of demyel ...... a proteolytic enzyme, calpain.
@en
P2093
D C Shields
K E Schaecher
P2860
P304
11486-11491
P356
10.1073/PNAS.96.20.11486
P407
P577
1999-09-01T00:00:00Z