Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates.
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Improving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed EvolutionReshaping an enzyme binding pocket for enhanced and inverted stereoselectivity: use of smallest amino acid alphabets in directed evolutionOlefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 EnzymesEnhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library.Enantioselective imidation of sulfides via enzyme-catalyzed intermolecular nitrogen-atom transferA single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.Directed evolution of RebH for site-selective halogenation of large biologically active molecules.Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-H amination.Cytochrome P450: taming a wild type enzymeCombinatorial library based engineering of Candida antarctica lipase A for enantioselective transacylation of sec-alcohols in organic solvent.A Simple Combinatorial Codon Mutagenesis Method for Targeted Protein EngineeringConstructing de novo biosynthetic pathways for chemical synthesis inside living cells.Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis.Cytochrome P450-Catalyzed Insertion of Carbenoids into N-H Bonds.P450-catalyzed intramolecular sp(3) C-H amination with arylsulfonyl azide substrates.P450(BM3) (CYP102A1): connecting the dots.Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis.Recent advances in engineering proteins for biocatalysis.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Accessing Drug Metabolites via Transition-Metal Catalyzed C-H Oxidation: The Liver as Synthetic Inspiration.Achieving regio- and enantioselectivity of P450-catalyzed oxidative CH activation of small functionalized molecules by structure-guided directed evolution.Aldehyde and Ketone Synthesis by P450-Catalyzed Oxidative Deamination of Alkyl Azides.Enantioselective Total Synthesis of Nigelladine A via Late-Stage C-H Oxidation Enabled by an Engineered P450 Enzyme.Crystal structure and iterative saturation mutagenesis of ChKRED20 for expanded catalytic scope.CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivitySurvey of protein engineering strategiesRegio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolutionP450 BM3 Monooxygenase as an Efficient NAD(P)H-Oxidase for Regeneration of Nicotinamide Cofactors in ADH-Catalysed Preparative Scale Biotransformations
P2860
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P2860
Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Combinatorial alanine substitu ...... oxylation of large substrates.
@ast
Combinatorial alanine substitu ...... oxylation of large substrates.
@en
type
label
Combinatorial alanine substitu ...... oxylation of large substrates.
@ast
Combinatorial alanine substitu ...... oxylation of large substrates.
@en
prefLabel
Combinatorial alanine substitu ...... oxylation of large substrates.
@ast
Combinatorial alanine substitu ...... oxylation of large substrates.
@en
P2093
P2860
P356
P1433
P1476
Combinatorial alanine substitu ...... oxylation of large substrates.
@en
P2093
Chi-Huey Wong
Jared C Lewis
Russell S Komor
Simone M Mantovani
P2860
P304
P356
10.1002/CBIC.201000565
P577
2010-12-01T00:00:00Z