Molecular insights into regulation of JAK2 in myeloproliferative neoplasms - Wikidata - awgldk - TriplyDB

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

http://www.wikidata.org/entity/Q35661987

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Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation The evolving world of pseudoenzymes: proteins, prejudice and zombies New Strategies in Myeloproliferative Neoplasms: The Evolving Genetic and Therapeutic Landscape.Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms.Gene expression profiling of acute type A aortic dissection combined with in vitroassessment†.O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.How Does the L884P Mutation Confer Resistance to Type-II Inhibitors of JAK2 Kinase: A Comprehensive Molecular Modeling Study.What are the challenges in 2016 regarding resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and cancer?Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase.Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.Resveratrol selectively induces apoptosis in malignant cells with the JAK2V617F mutation by inhibiting the JAK2 pathway.Cytokine Receptors

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P2860

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

http://www.wikidata.org/entity/Q35661987

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

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Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

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type

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Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

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Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

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prefLabel

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

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Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

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BLOOD-2015-01-621110

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Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

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Olli Silvennoinen

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P2860

Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2

Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

The Jak-Stat pathway in normal and perturbed hematopoiesis

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Structural and functional basis for JAK3-deficient severe combined immunodeficiency

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

Jak2 is essential for signaling through a variety of cytokine receptors

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3388-3392

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scholarly article

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10.1182/BLOOD-2015-01-621110

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22

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Stevan R Hubbard

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