Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production
about
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screenThe role of STAT3 in autophagyA Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell InvasionNiclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer.Drug repositioning: a machine-learning approach through data integration.A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans.Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.Small molecule modulators of Wnt/β-catenin signaling.Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide.Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposureEffect of niclosamide on basal-like breast cancers.Current drug targets for helminthic diseases.Existing drugs and their application in drug discovery targeting cancer stem cells.Inhibition of Wnt/β-catenin by anthelmintic drug niclosamide effectively targets growth, survival, and angiogenesis of retinoblastoma.Combined niclosamide with cisplatin inhibits epithelial-mesenchymal transition and tumor growth in cisplatin-resistant triple-negative breast cancer.Niclosamide suppresses renal cell carcinoma by inhibiting Wnt/β-catenin and inducing mitochondrial dysfunctions.Niclosamide As a Potential Nonsteroidal Therapy for Endometriosis That Preserves Reproductive Function in an Experimental Mouse Model.The Anthelmintic Drug Niclosamide and its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis.Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial.Preferential Inhibition of Wnt/β-Catenin Signaling by Novel Benzimidazole Compounds in Triple-Negative Breast Cancer.A phase I study of niclosamide in combination with enzalutamide in men with castration-resistant prostate cancer.Niclosamide sensitizes nasopharyngeal carcinoma to radiation by downregulating Ku70/80 expression.
P2860
Q26747306-B3764A32-16B0-4886-B54B-5F892C732B9CQ28084959-EA586FB0-F718-43BD-B226-709B6AD02F1AQ28552623-2C1476EB-D3F1-4F49-9154-3DEBCC1A6D3CQ30275354-988FB55A-667A-4358-80F2-26B31C8F50A1Q30651571-6DE945CF-6F3C-4AFF-97E5-3980C04A4928Q33749557-01B8E227-C2FB-40B6-93F4-FDCE543E6861Q34199032-F13D6457-EF9D-49A2-8344-23817EA91D10Q34604768-72172FC0-9000-401D-AA81-9586A0E60DF6Q36083012-167562E1-4847-4F76-AD48-6EC4CE68AB02Q36454906-147E1D85-8148-4070-B0E5-2FE7C39CBAE8Q37695022-0F46B0FC-DD97-4565-B041-8AF810F35E5BQ38093067-F0DDBC56-6708-4CC4-BE04-A5C348B5466BQ38543730-D8730DF7-F708-464F-AC53-85A84A70A11AQ38598774-F3AE466D-6BD2-4C9D-94FD-5FC111F347F0Q38799468-BF280F52-2910-48E2-A4BA-D9B94FF2DA0CQ39367715-78BBA871-E1C5-449F-B21A-35A822E7DF10Q41634189-63F264EE-7045-4A2E-8FD2-4A8E6BA439FAQ47309289-80B1C865-EE3D-49E3-B7BD-4CD0FE58C69DQ51124579-92B83CB3-F587-4BF4-B9B3-0306A4F120F3Q52807468-120CEB76-133E-4725-BB03-AA740407257BQ55038918-BDB28CB1-F412-4110-BD35-5211002826D2Q55208854-40CFE63A-6760-49BC-9751-DF9140EB043DQ55244874-463C41B4-2E59-41CC-8C14-CD918D6B8701
P2860
Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Redeployment-based drug screen ...... es free light chain production
@ast
Redeployment-based drug screen ...... es free light chain production
@en
type
label
Redeployment-based drug screen ...... es free light chain production
@ast
Redeployment-based drug screen ...... es free light chain production
@en
prefLabel
Redeployment-based drug screen ...... es free light chain production
@ast
Redeployment-based drug screen ...... es free light chain production
@en
P2093
P2860
P356
P1433
P1476
Redeployment-based drug screen ...... es free light chain production
@en
P2093
B A M E Merrick
F L Khanim
J B Jackson
J Birtwistle
M T Drayson
P2860
P2888
P356
10.1038/BCJ.2011.38
P50
P577
2011-10-21T00:00:00Z