Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity
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Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesisFgd5 identifies hematopoietic stem cells in the murine bone marrow.Mutations in MECOM, Encoding Oncoprotein EVI1, Cause Radioulnar Synostosis with Amegakaryocytic ThrombocytopeniaHematopoietic transcription factor mutations: important players in inherited platelet defects.Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.Use of Imaging Techniques to Illuminate Dynamics of Hematopoietic Stem Cells and Their NichesTissue-specific upregulation of MDS/EVI gene transcripts in the intestine by thyroid hormone during Xenopus metamorphosis.EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cellsSurvivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1CDK6 levels regulate quiescence exit in human hematopoietic stem cells.Embryonic Hematopoietic Progenitor Cells Reside in Muscle before Bone Marrow HematopoiesisEVI1, a target gene for amplification at 3q26, antagonizes transforming growth factor-β-mediated growth inhibition in hepatocellular carcinoma.The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia.The Janus-faced Nature of miR-22 in Hematopoiesis: Is It an Oncogenic Tumor Suppressor or Rather a Tumor-Suppressive Oncogene?CD150(-) Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.Reviewing and updating the major molecular markers for stem cellsBRPF1 is essential for development of fetal hematopoietic stem cellsEcotropic viral integration site 1, stem cell self-renewal and leukemogenesis.New approaches to expand hematopoietic stem and progenitor cells.Genetic events other than BCR-ABL1.The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL.Hematopoietic stem cells: concepts, definitions, and the new reality.Mechanisms of self-renewal in hematopoietic stem cells.Human haematopoietic stem cell lineage commitment is a continuous processEVI1 and MDS1/EVI1 expression during primary human hematopoietic progenitor cell differentiation into various myeloid lineages.Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression.The bone marrow microenvironment as niche retreats for hematopoietic and leukemic stem cells.The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult AnimalsContinuous cell supply from Krt7-expressing hematopoietic stem cells during native hematopoiesis revealed by targeted in vivo gene transfer method.Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus.Identification of hematopoietic-specific regulatory elements from the CD45 gene and use for lentiviral tracking of transplanted cells.Aberrant expression of ecotropic viral integration site-1 in acute myeloid leukemia and acute lymphoblastic leukemia.Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence.EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemia.Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes.
P2860
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P2860
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Evi1 is essential for hematopo ...... ilineage repopulating activity
@ast
Evi1 is essential for hematopo ...... ilineage repopulating activity
@en
type
label
Evi1 is essential for hematopo ...... ilineage repopulating activity
@ast
Evi1 is essential for hematopo ...... ilineage repopulating activity
@en
prefLabel
Evi1 is essential for hematopo ...... ilineage repopulating activity
@ast
Evi1 is essential for hematopo ...... ilineage repopulating activity
@en
P2093
P2860
P356
P1476
Evi1 is essential for hematopo ...... ilineage repopulating activity
@en
P2093
Akihide Yoshimi
Hiroshi Kobayashi
Katsuyoshi Kumagai
Keiki Kumano
Keisuke Kataoka
Masahiro Nakagawa
Mineo Kurokawa
Munetake Shimabe
Naoto Kubota
Shunya Arai
P2860
P304
P356
10.1084/JEM.20110447
P407
P577
2011-11-14T00:00:00Z