Rational redesign of the folding pathway of a modular protein
about
Protein folding: then and nowStructural Analyses of the Ankyrin Repeat Domain of TRPV6 and Related TRPV Ion Channels † , ‡Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain foldDiscrete kinetic models from funneled energy landscape simulationsDirect observation of parallel folding pathways revealed using a symmetric repeat protein system.Mechanical unfolding of an ankyrin repeat protein.Take home lessons from studies of related proteinsEffects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrinComplex energy landscape of a giant repeat protein.Highly polarized C-terminal transition state of the leucine-rich repeat domain of PP32 is governed by local stability.Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein.Modulation of folding kinetics of repeat proteins: interplay between intra- and interdomain interactions.Rerouting the folding pathway of the Notch ankyrin domain by reshaping the energy landscapeShifting transition states in the unfolding of a large ankyrin repeat proteinThe capillarity picture and the kinetics of one-dimensional protein foldingRepeat-protein folding: new insights into origins of cooperativity, stability, and topology.Folding landscapes of ankyrin repeat proteins: experiments meet theory.Long-range effects and functional consequences of stabilizing mutations in the ankyrin repeat domain of IκBα.Structural analysis of a beta-helical protein motif stabilized by targeted replacements with conformationally constrained amino acids.Exploring the folding energy landscape of a series of designed consensus tetratricopeptide repeat proteins.Molecular mechanisms of system control of NF-kappaB signaling by IkappaBalphaWhat lessons can be learned from studying the folding of homologous proteins?Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks.The leucine-rich repeat domain of Internalin B folds along a polarized N-terminal pathway.Sequential four-state folding/unfolding of goat α-lactalbumin and its N-terminal variants.Pre-folding IkappaBalpha alters control of NF-kappaB signaling.Mapping the energy landscape of repeat proteins using NMR-detected hydrogen exchangeDiffuse transition state structure for the unfolding of a leucine-rich repeat protein.Ising Model Reprogramming of a Repeat Protein's Equilibrium Unfolding Pathway.What have we learned from the studies of two-state folders, and what are the unanswered questions about two-state protein folding?Folding kinetics of the cooperatively folded subdomain of the IκBα ankyrin repeat domain.Modulation of the multistate folding of designed TPR proteins through intrinsic and extrinsic factors.Capping motifs stabilize the leucine-rich repeat protein PP32 and rigidify adjacent repeats.Folding thermodynamics and kinetics of the leucine-rich repeat domain of the virulence factor Internalin BNon-random-coil behavior as a consequence of extensive PPII structure in the denatured state.Single-molecule FRET reveals hidden complexity in a protein energy landscape.
P2860
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P2860
Rational redesign of the folding pathway of a modular protein
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Rational redesign of the folding pathway of a modular protein
@ast
Rational redesign of the folding pathway of a modular protein
@en
type
label
Rational redesign of the folding pathway of a modular protein
@ast
Rational redesign of the folding pathway of a modular protein
@en
prefLabel
Rational redesign of the folding pathway of a modular protein
@ast
Rational redesign of the folding pathway of a modular protein
@en
P2860
P356
P1476
Rational redesign of the folding pathway of a modular protein
@en
P2093
Alan R Lowe
Laura S Itzhaki
P2860
P304
P356
10.1073/PNAS.0604653104
P407
P577
2007-02-13T00:00:00Z