Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.
about
ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.The molecular mechanics of mixed lineage leukemia.Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature.Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemiaMolecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia.Predicting Chemotherapy Resistance in AML.The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9.Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model.Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.Copy number profiling of adult relapsed B-cell precursor acute lymphoblastic leukemia reveals potential leukemia progression mechanisms.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.DNA methylation profile in chronic myelomonocytic leukemia associates with distinct clinical, biological and genetic features.CTCF boundary remodels chromatin domain and drives aberrant gene transcription in acute myeloid leukemia
P2860
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P2860
Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Epigenomic analysis of the HOX ...... nd normal hematopoietic cells.
@ast
Epigenomic analysis of the HOX ...... nd normal hematopoietic cells.
@en
type
label
Epigenomic analysis of the HOX ...... nd normal hematopoietic cells.
@ast
Epigenomic analysis of the HOX ...... nd normal hematopoietic cells.
@en
prefLabel
Epigenomic analysis of the HOX ...... nd normal hematopoietic cells.
@ast
Epigenomic analysis of the HOX ...... nd normal hematopoietic cells.
@en
P2093
P2860
P356
P1433
P1476
Epigenomic analysis of the HOX ...... nd normal hematopoietic cells.
@en
P2093
C A Miller
D H Spencer
M O'Laughlin
N M Helton
R K Wilson
R T Demeter
P2860
P2888
P304
P356
10.1038/LEU.2015.6
P577
2015-01-20T00:00:00Z