The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens
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From the Outside-In: The Francisella tularensis Envelope and VirulenceSubversion of host recognition and defense systems by Francisella sppComparative review of Francisella tularensis and Francisella novicidaLive attenuated Francisella novicida vaccine protects against Francisella tularensis pulmonary challenge in rats and non-human primatesSystems approach to investigating host-pathogen interactions in infections with the biothreat agent Francisella. Constraints-based model of Francisella tularensisEffective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigensMutations of Francisella novicida that alter the mechanism of its phagocytosis by murine macrophagesCurrent status of vaccine development for tularemia preparedness.Azithromycin effectiveness against intracellular infections of Francisella.Identification of genes contributing to the virulence of Francisella tularensis SCHU S4 in a mouse intradermal infection modelA Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge.Glutathione provides a source of cysteine essential for intracellular multiplication of Francisella tularensis.The type IV pilin, PilA, is required for full virulence of Francisella tularensis subspecies tularensis.Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages.Development of ELISAs for diagnosis of acute typhoid fever in Nigerian children.Roles for wbtC, wbtI, and kdtA Genes in Lipopolysaccharide Biosynthesis, Protein Glycosylation, Virulence, and Immunogenicity in Francisella tularensis2 Strain SCHU S4.A Francisella tularensis live vaccine strain (LVS) mutant with a deletion in capB, encoding a putative capsular biosynthesis protein, is significantly more attenuated than LVS yet induces potent protective immunity in mice against F. tularensis chalTularemia vaccines: recent developments and remaining hurdles.Comprehensive biothreat cluster identification by PCR/electrospray-ionization mass spectrometry.Genetic diversity within the genus Francisella as revealed by comparative analyses of the genomes of two North American isolates from environmental sources.Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in miceIsolation and mutagenesis of a capsule-like complex (CLC) from Francisella tularensis, and contribution of the CLC to F. tularensis virulence in miceCommon ancestry and novel genetic traits of Francisella novicida-like isolates from North America and Australia as revealed by comparative genomic analyses.Glycosylation of DsbA in Francisella tularensis subsp. tularensis.Characterization of Francisella tularensis Schu S4 mutants identified from a transposon library screened for O-antigen and capsule deficienciesA defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity.O-antigen-deficient Francisella tularensis Live Vaccine Strain mutants are ingested via an aberrant form of looping phagocytosis and show altered kinetics of intracellular trafficking in human macrophages.Genetic modification of the O-polysaccharide of Francisella tularensis results in an avirulent live attenuated vaccine.Genome-wide identification of Francisella tularensis virulence determinantsCharacterization of protein glycosylation in Francisella tularensis subsp. holarctica: identification of a novel glycosylated lipoprotein required for virulence.Francisella novicida bacteremia after a near-drowning accidentIdentification of Francisella tularensis Himar1-based transposon mutants defective for replication in macrophagesA spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia.The structure and function of Francisella lipopolysaccharideThe Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host.Tularemia vaccine development: paralysis or progress?Metabolic labeling to characterize the overall composition of Francisella lipid A and LPS grown in broth and in human phagocytes.Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes.Comparative phosphoproteomics reveals components of host cell invasion and post-transcriptional regulation during Francisella infection.Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development.
P2860
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P2860
The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The immunologically distinct O ...... inants and protective antigens
@ast
The immunologically distinct O ...... inants and protective antigens
@en
type
label
The immunologically distinct O ...... inants and protective antigens
@ast
The immunologically distinct O ...... inants and protective antigens
@en
prefLabel
The immunologically distinct O ...... inants and protective antigens
@ast
The immunologically distinct O ...... inants and protective antigens
@en
P2093
P2860
P356
P1476
The immunologically distinct O ...... inants and protective antigens
@en
P2093
Emma Waters
I Darren Grice
Jennifer C Wilson
Joann L Prior
Kate Griffin
Paul G Hitchen
Petra C F Oyston
Rebecca M Thomas
Stephen L Michell
P2860
P304
P356
10.1128/IAI.01241-06
P407
P577
2006-10-30T00:00:00Z