Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders. - Wikidata - awgldk - TriplyDB

Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders.

Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders.

http://www.wikidata.org/entity/Q35690145

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Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson's disease Characterization of a Novel -Conotoxin from Conus textile That Selectively Targets 6/ 3 2 3 Nicotinic Acetylcholine Receptors A novel 4/7-conotoxin LvIA from Conus lividus that selectively blocks 3 2 vs. 6/ 3 2 3 nicotinic acetylcholine receptors Role for α6 nicotinic receptors in l-dopa-induced dyskinesias in parkinsonian mice Progress and challenges in the study of α6-containing nicotinic acetylcholine receptors.Acute ethanol inhibits dopamine release in the nucleus accumbens via α6 nicotinic acetylcholine receptors The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile.Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.Low concentrations of nicotine differentially desensitize nicotinic acetylcholine receptors that include α5 or α6 subunits and that mediate synaptosomal neurotransmitter release Nicotine reduces antipsychotic-induced orofacial dyskinesia in rats.Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake.Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions Diurnal Evening Type is Associated with Current Smoking, Nicotine Dependence and Nicotine Intake in the Population Based National FINRISK 2007 Study Chronic Nicotine Exposure Attenuates Methamphetamine-Induced Dopaminergic Deficits.Varenicline and nicotine enhance GABAergic synaptic transmission in rat CA1 hippocampal and medial septum/diagonal band neurons.Nicotine-mediated improvement in L-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal function α4β2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats.Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum.Optimal cleavage and oxidative folding of α-conotoxin TxIB as a therapeutic candidate peptide Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.Diverse strategies targeting α7 homomeric and α6β2* heteromeric nicotinic acetylcholine receptors for smoking cessation.Elucidation of molecular impediments in the α6 subunit for in vitro expression of functional α6β4* nicotinic acetylcholine receptors.COPI polices nicotine-mediated up-regulation of nicotinic receptors.Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.α6β2*-subtype nicotinic acetylcholine receptors are more sensitive than α4β2*-subtype receptors to regulation by chronic nicotine administration.Deletion of lynx1 reduces the function of α6* nicotinic receptors.α6β2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption.Expression in Escherichia coli of fusion protein comprising α-conotoxin TxIB and preservation of selectivity to nicotinic acetylcholine receptors in the purified product.The striatal cholinergic system in L-dopa-induced dyskinesias.Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons.

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P2860

Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders.

http://www.wikidata.org/entity/Q35690145

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J.BCP.2011.06.001

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Biochemical Pharmacology

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Role of α6 nicotinic receptors ...... on and neurological disorders.

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Maryka Quik

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Sharon R Grady

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Xiomara A Perez

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P2860

Nicotine addiction

In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors

Desensitization of nicotinic acetylcholine receptors as a strategy for drug development.

Mammalian nicotinic acetylcholine receptors: from structure to function

Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration

The neuronal nicotinic acetylcholine receptors alpha 4* and alpha 6* differentially modulate dopamine release in mouse striatal slices

A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors

Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors

Use of a snake venom toxin to characterize the cholinergic receptor protein

Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

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