Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy.
about
Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewAnimal and in silico models for the study of sarcomeric cardiomyopathiesFibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathyCardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeLong term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathyThe cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin CStructure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugsTNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin IConstitutive phosphorylation of cardiac myosin regulatory light chain in vivoThe R21C Mutation in Cardiac Troponin I Imposes Differences in Contractile Force Generation between the Left and Right Ventricles of Knock-In MiceTroponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.Uncoupling of myofilament Ca2+ sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate.Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation.Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation.Inherited cardiomyopathies caused by troponin mutations.Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.Contribution of Post-translational Phosphorylation to Sarcomere-Linked Cardiomyopathy Phenotypes.Top-down Proteomics: Technology Advancements and Applications to Heart Diseases.Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy.Cardiac troponin I phosphorylation and the force-length relationship.
P2860
Q21129229-E94395BA-5C9D-4FEF-AC3D-C505DA76A9F0Q26865437-639D58AB-DF31-44D8-BB77-11EADD7848F4Q27342077-58AA89A8-F146-4EA2-8039-ACD1FDA377CAQ28066435-CBD8B676-47F2-4A0D-9619-83EEB3AF6CCCQ28242903-49898575-43B3-4051-95F1-D5508289EBB9Q28248504-AA96479C-EE11-4739-BBD5-2518CCF69AC0Q28607749-C01B756B-38FB-4384-BE71-FBF148DB1A28Q30380968-6FEF7C95-FEE4-4AEA-91CD-32F77F0D66B5Q34080849-F420188E-BD78-4D2E-BBC7-BBE184595A73Q34561329-1183578D-F026-454F-9DFB-9E2C912CD7E3Q35536235-A1AFFC51-A4CF-4E4F-8748-893CC474B2A5Q35556610-0F58E0AB-A12C-4F30-9506-F67A21ADF51AQ36282901-7784F468-6E01-4BDF-B96A-23E6C5CA24DEQ36998382-642A60E0-F61D-4C4C-8F8B-93152E9C3409Q37009456-76012B03-8BDE-43FA-85BD-E2B38D8FF1EAQ37211593-389EF983-1344-4041-8315-51B970D3985EQ38101039-1BE0D4EE-AA5B-46ED-8B1C-FF6B8E14433FQ38724869-A7E740D7-2822-4B63-A9BD-C714B25A63A9Q38816583-B9189263-51FC-4D93-9C16-26644837AD52Q38905767-AD643790-1F28-4C3B-9A75-601892760934Q41949346-17801DD3-59E8-4A46-9422-D545DFFF09CFQ42069498-86E98827-E884-4CB6-93A2-9D00E5BAC846Q43480355-B8D88FB5-3B1C-48E2-A713-CB00493E9ACC
P2860
Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Generation and functional char ...... h hypertrophic cardiomyopathy.
@ast
Generation and functional char ...... h hypertrophic cardiomyopathy.
@en
type
label
Generation and functional char ...... h hypertrophic cardiomyopathy.
@ast
Generation and functional char ...... h hypertrophic cardiomyopathy.
@en
prefLabel
Generation and functional char ...... h hypertrophic cardiomyopathy.
@ast
Generation and functional char ...... h hypertrophic cardiomyopathy.
@en
P2093
P2860
P356
P1476
Generation and functional char ...... h hypertrophic cardiomyopathy.
@en
P2093
David Dweck
James D Potter
Jeffery W Walker
Jingsheng Liang
Jose Renato Pinto
Raquel Sancho Solis
Yingcai Wang
Zoraida Diaz-Perez
P2860
P304
P356
10.1074/JBC.M111.294306
P407
P577
2011-11-15T00:00:00Z