Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G1 extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase.
about
Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityPhosphorylation of replication protein A middle subunit (RPA32) leads to a disassembly of the RPA heterotrimerRBT1, a novel transcriptional co-activator, binds the second subunit of replication protein ADNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchangeBacterial single-stranded DNA-binding proteins are phosphorylated on tyrosine.RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage responseIn vitro analysis of the zinc-finger motif in human replication protein AUV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.Regulation of dna replication after heat shock by replication protein a-nucleolin interactions.Re-oxygenation of hypoxic simian virus 40 (SV40)-infected CV1 cells causes distinct changes of SV40 minichromosome-associated replication proteins.Replication protein A (RPA) phosphorylation prevents RPA association with replication centers.Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B.Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responsesSequential and synergistic modification of human RPA stimulates chromosomal DNA repair.RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage.Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stressReplication protein A: directing traffic at the intersection of replication and repair.Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development.The BCL2 major breakpoint region is a sequence- and cell-cycle-specific binding site of the Ku antigenInteraction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies.RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.Phosphorylated and unphosphorylated forms of human single-stranded DNA-binding protein are equally active in simian virus 40 DNA replication and in nucleotide excision repair.Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro.Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells.Phosphorylation of human replication protein A by the DNA-dependent protein kinase is involved in the modulation of DNA replicationCatalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.Formation of a complex between nucleolin and replication protein A after cell stress prevents initiation of DNA replicationscid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase.Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinaseEvidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle.The role of the 34-kDa subunit of human replication protein A in simian virus 40 DNA replication in vitro.Dissection of functional domains of the human DNA replication protein complex replication protein A.Studies on the in vitro phosphorylation of HSSB-p34 and -p107 by cyclin-dependent kinases. Cyclin-substrate interactions dictate the efficiency of phosphorylation.The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast.Sequence-specific binding of Ku autoantigen to single-stranded DNA.Purification, gene cloning, and reconstitution of the heterotrimeric single-stranded DNA-binding protein from Schizosaccharomyces pombe.The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replicationHypersensitivity of Ku-deficient cells toward the DNA topoisomerase II inhibitor ICRF-193 suggests a novel role for Ku antigen during the G2 and M phases of the cell cycle.
P2860
Q21263027-2CD90808-7DE7-423F-A5CC-46AB097F2B45Q22010062-C3487381-69A5-4FED-99EA-D693EBDAC914Q24290232-3CA5375D-C62A-4AC1-9EE0-32C4BF5F138FQ24311527-40A4D00E-E505-4AF5-84B2-848104040C3CQ25255885-E367CB0F-5F1A-477C-A90D-D3C60B36ABF3Q26827954-B40A38E6-A546-46C8-A6D8-90FB1B022042Q28610870-2D709B0C-55B4-4ACF-84DC-9583512E6318Q30662249-2177233D-A101-4F8D-BE3D-E31016D2DC5EQ30673624-3FB5EA44-E963-4706-8DA4-FA4BE18659E7Q30835095-2DA17B64-7DFB-4712-863F-093202E033F6Q31048017-8262AD8A-8048-4F9E-81B4-8DE6D2986FC7Q33218577-094B43C5-70D2-46DB-9706-3EB9C2791A40Q33235763-83F5D5EE-CC3C-468D-B8CF-A57CEB0A5C68Q33302234-B286645C-87E1-41FB-A782-17B2C97EEF6BQ33362855-1D9134A8-7F93-4720-A04B-CD51FC35BFCEQ33511571-60195D06-5F90-462A-ADC5-CF0878D14542Q33591901-AF2559A7-8ABA-430C-AF27-5A0B9192F910Q33713030-F095A2C3-30EE-47F9-8FC7-35E39375EF98Q33821352-D7E8C6EB-A4B4-4FC1-9B05-120AED3711BCQ33887333-43AC283B-8F3B-477E-A256-B6013FFE983FQ33894393-9835BCFA-6F0A-49FA-A79F-AB2962502867Q34353315-4FB0BD0D-B711-4C9F-A780-C4086AD7362EQ34414504-C5B67542-89A2-4CD5-8D61-FBD62FED4D47Q34424988-60B7EC29-1AD2-4026-84FB-7FD796EE04D3Q34439017-A85355CF-BE22-4ED3-AA71-2BE4CAA36986Q34604946-9CEAEF11-8A0F-419B-BC82-5F0DF53FA22BQ34992049-9165225B-8D20-4951-88A7-6457E516802AQ35932187-EFFB3AC9-365A-42CF-BA12-0ADE08B2CAD6Q36327063-A7E94463-73A7-4B5E-898B-C405AE6C356FQ36555430-37B43764-50EF-4430-81E3-196AB210E08EQ36562044-75A3865A-1F09-4713-BC1B-D9CA1B81D9D5Q36565894-CFD2E502-F708-4F77-8E83-AF161740CAB9Q36704503-01B4C3EB-191C-4B9B-A91C-E8CC59697A5EQ36802969-72D72655-BD6A-4DB2-AF58-1A27029F7C71Q36818739-1A72F74D-3830-4B85-BC0B-72795D855A9CQ36823107-873D44A3-AA59-45F3-B5D6-ECECAC5ECD62Q38334674-0B2880CA-1E9A-4657-9707-8AC26D7A36B2Q38353881-737C0B4B-9274-49CC-8213-D5FD53C66EEBQ39542617-97D42284-8934-4498-A5A6-F2C1C47EA4BFQ39576173-0C721CA3-6091-4142-882F-535C6AC79030
P2860
Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G1 extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Phosphorylation of the p34 sub ...... DNA-dependent protein kinase.
@ast
Phosphorylation of the p34 sub ...... DNA-dependent protein kinase.
@en
type
label
Phosphorylation of the p34 sub ...... DNA-dependent protein kinase.
@ast
Phosphorylation of the p34 sub ...... DNA-dependent protein kinase.
@en
prefLabel
Phosphorylation of the p34 sub ...... DNA-dependent protein kinase.
@ast
Phosphorylation of the p34 sub ...... DNA-dependent protein kinase.
@en
P2093
P2860
P356
P1476
Phosphorylation of the p34 sub ...... DNA-dependent protein kinase.
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.18.8343
P407
P577
1994-08-01T00:00:00Z