Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy. - Wikidata - awgldk - TriplyDB

Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy.

Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy.

http://www.wikidata.org/entity/Q35701287

about

Customizing the genome as therapy for the β-hemoglobinopathies Towards a new era in medicine: therapeutic genome editing Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges Application of genomics-assisted breeding for generation of climate resilient crops: progress and prospects Modelling human disease with pluripotent stem cells Quantifying on- and off-target genome editing Homing endonucleases: DNA scissors on a mission 5'-Cytosine-Phosphoguanine (CpG) Methylation Impacts the Activity of Natural and Engineered Meganucleases Structural mechanisms of the degenerate sequence recognition by Bse634I restriction endonuclease CRISPR-Cas systems for editing, regulating and targeting genomes Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing.Genome-Edited T Cell Therapies.Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues.Improved modeling of side-chain--base interactions and plasticity in protein--DNA interface design Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases.Genome engineering empowers the diatom Phaeodactylum tricornutum for biotechnology.Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy.MAR elements and transposons for improved transgene integration and expression Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9 TALE-PvuII fusion proteins--novel tools for gene targeting.Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition.Efficient design of meganucleases using a machine learning approach.Homing endonucleases: from genetic anomalies to programmable genomic clippers Rapid prototyping of microbial cell factories via genome-scale engineering.Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.Using Group II Introns for Attenuating the In Vitro and In Vivo Expression of a Homing Endonuclease Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein.CRISPR-Cas9-mediated genome editing and guide RNA design.Controlled delivery of β-globin-targeting TALENs and CRISPR/Cas9 into mammalian cells for genome editing using microinjection Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells.Quantitative analysis of TALE-DNA interactions suggests polarity effects.The genetic basis of severe combined immunodeficiency and its variants.A genome editing primer for the hematologist Discovery of Nigri/nox and Panto/pox site-specific recombinase systems facilitates advanced genome engineering CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells.Reprogramming homing endonuclease specificity through computational design and directed evolution.Programmable Genome Editing Tools and their Regulation for Efficient Genome Engineering.The Development of TALE Nucleases for Biotechnology.Redesign of extensive protein-DNA interfaces of meganucleases using iterative cycles of in vitro compartmentalization.

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P2860

Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy.

http://www.wikidata.org/entity/Q35701287

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Meganucleases and other tools ...... d challenges for gene therapy.

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Meganucleases and other tools ...... d challenges for gene therapy.

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Meganucleases and other tools ...... d challenges for gene therapy.

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Meganucleases and other tools ...... d challenges for gene therapy.

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Meganucleases and other tools ...... d challenges for gene therapy.

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Meganucleases and other tools ...... d challenges for gene therapy.

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Current Gene Therapy

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Meganucleases and other tools ...... d challenges for gene therapy.

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Frédéric Pâques

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George Silva

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Guillermo Montoya

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Julianne Smith

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Laurent Poirot

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Creative Commons Attribution 2.5 Unported

P2860

Inteins, introns, and homing endonucleases: recent revelations about the life cycle of parasitic genetic elements

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta

Gene targeting in stem cells from individuals with osteogenesis imperfecta

Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells

Mutations altering the cleavage specificity of a homing endonuclease

Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

Computational redesign of endonuclease DNA binding and cleavage specificity

TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

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biomedical investigative technique

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