Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.
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C-S bond cleavage by a polyketide synthase domain.Synthesis of 3,3'-di-O-methyl ardimerin and exploration of its DNA binding properties.Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen speciesSynthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural productCharacterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.Chemical structure and properties of interstrand cross-links formed by reaction of guanine residues with abasic sites in duplex DNASynthesis and characterization of a small analogue of the anticancer natural product leinamycin.Muscarine, imidaozle, oxazole and thiazole alkaloids.Biosynthesis of polyketides by trans-AT polyketide synthases.Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics.Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics.Oxidative activation of leinamycin E1 triggers alkylation of guanine residues in double-stranded DNA.
P2860
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P2860
Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Noncovalent DNA binding drives ...... an atypical DNA intercalator.
@ast
Noncovalent DNA binding drives ...... an atypical DNA intercalator.
@en
type
label
Noncovalent DNA binding drives ...... an atypical DNA intercalator.
@ast
Noncovalent DNA binding drives ...... an atypical DNA intercalator.
@en
prefLabel
Noncovalent DNA binding drives ...... an atypical DNA intercalator.
@ast
Noncovalent DNA binding drives ...... an atypical DNA intercalator.
@en
P2093
P2860
P356
P1476
Noncovalent DNA binding drives ...... s an atypical DNA intercalator
@en
P2093
Jozsef Szekely
Kent S Gates
Mostafa I Fekry
Sanjay Dutta
P2860
P304
17641-17651
P356
10.1021/JA2046149
P407
P577
2011-10-18T00:00:00Z