Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability - Wikidata - awgldk - TriplyDB

Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability

Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability

http://www.wikidata.org/entity/Q35709981

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Posttranslational modifications in connexins and pannexins Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair.Increase of gap junction activities in SW480 human colorectal cancer cells.Synergistic effects of AKAP95, Cyclin D1, Cyclin E1, and Cx43 in the development of rectal cancer.Targeting connexin 43 with α-connexin carboxyl-terminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer: clinical implication for ACT1 Prognostic impact of reduced connexin43 expression and gap junction coupling of neoplastic stromal cells in giant cell tumor of bone Differential regulation of Connexin50 and Connexin46 by PI3K signaling.Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition.Redistribution of connexin 43 during cell division.Ubiquitination, intracellular trafficking, and degradation of connexins Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection Reciprocal positive regulation between Cx26 and PI3K/Akt pathway confers acquired gefitinib resistance in NSCLC cells via GJIC-independent induction of EMT.Designer gap junctions that prevent cardiac arrhythmias Mesenchymal stem cells improve cardiac conduction by upregulation of connexin 43 through paracrine signaling.Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75).A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor.Proteins and mechanisms regulating gap-junction assembly, internalization, and degradation.Managing the complexity of communication: regulation of gap junctions by post-translational modification.Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size.Connexins: mechanisms regulating protein levels and intercellular communication Degradation of connexins and gap junctions.Specific Cx43 phosphorylation events regulate gap junction turnover in vivo Molecular connexin partner remodeling orchestrates connexin traffic: from physiology to pathophysiology.AKT as locus of cancer angiogenic robustness and fragility.Degradation of connexins through the proteasomal, endolysosomal and phagolysosomal pathways.Regulation of connexin- and pannexin-based channels by post-translational modifications.Pannexin-1 channels and their emerging functions in cardiovascular diseases.Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive.The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions.AuNP-Collagen Matrix with Localized Stiffness for Cardiac-Tissue Engineering: Enhancing the Assembly of Intercalated Discs by β1-Integrin-Mediated Signaling.Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46: A Role in Preeclampsia?Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics.Connexin 43 and Mitochondria in Cardiovascular Health and Disease.The protein phosphatase 2A regulatory subunit Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition.Silver nanoparticles increase connexin43-mediated gap junctional intercellular communication in HaCaT cells through activation of reactive oxygen species and mitogen-activated protein kinase signal pathway.Dysfunction of mitochondria and deformed gap junctions in the heart of IL-18-deficient mice.Cardioprotection by PI3K-mediated signaling is required for anti-arrhythmia and myocardial repair in response to ischemic preconditioning in infarcted pig hearts.Role of connexin 43 in different forms of intercellular communication - gap junctions, extracellular vesicles and tunnelling nanotubes.Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.AKT Signaling Prevailing in Mesenchymal Stromal Cells Modulates the Functionality of Hematopoietic Stem Cells via Intercellular Communication.

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P2860

Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability

http://www.wikidata.org/entity/Q35709981

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2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Activation of Akt, not connexi ...... gulates gap junction stability

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Activation of Akt, not connexi ...... gulates gap junction stability

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Activation of Akt, not connexi ...... gulates gap junction stability

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Activation of Akt, not connexi ...... gulates gap junction stability

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prefLabel

Activation of Akt, not connexi ...... gulates gap junction stability

@ast

Activation of Akt, not connexi ...... gulates gap junction stability

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Journal of Biological Chemistry

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Activation of Akt, not connexi ...... gulates gap junction stability

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Alan F Lau

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Clarence A Dunn

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Paul D Lampe

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Vivian Su

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P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75

The E3 ligase TRAF6 regulates Akt ubiquitination and activation

Connexin mutations in X-linked Charcot-Marie-Tooth disease

Life cycle of connexins in health and disease

Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia

Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101

Endocytic processing of connexin43 gap junctions: a morphological study

Eps15 interacts with ubiquitinated Cx43 and mediates its internalization

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protein ubiquitination

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3268419

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